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Computational biophysicist Ada Sedova is using experiments and high-performance computing to explore the properties of biological systems and predict their form and function, including research to accelerate drug discovery for COVID-19. Photo credit: Jason Richards, Oak Ridge National Laboratory, U.S. Dept. of Energy.

Ada Sedova’s journey to Oak Ridge National Laboratory has taken her on the path from pre-med studies in college to an accelerated graduate career in mathematics and biophysics and now to the intersection of computational science and biology

The protease protein is both shaped like a heart and functions as one, allowing the virus replicate and spread. Inhibiting the protease would block virus reproduction. Credit: Andrey Kovalevsky/ORNL, U.S. Dept. of Energy

A team of researchers has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease — the enzyme that enables the virus to reproduce.

Ecosystem Ecologist Verity Salmon captures and analyzes field data from sites in in Alaska and Minnesota to inform earth system models that are being used to predict environmental change.

While some of her earth system modeling colleagues at ORNL face challenges such as processor allocation or debugging code, Verity Salmon prepares for mosquito swarms and the possibility of grizzly bears.

Data scientists at Oak Ridge National Laboratory have completed a study of long-term trends in the relationship between the timing of tree leafing and rising temperatures in the United States. The information is being incorporated into DOE’s Energy Exascale Earth System Model. Photo Credit: Oak Ridge National Laboratory, U.S. Dept. of Energy

A team of scientists led by Oak Ridge National Laboratory found that while all regions of the country can expect an earlier start to the growing season as temperatures rise, the trend is likely to become more variable year-over-year in hotter regions.

Illustration of a nitrogen dioxide molecule (depicted in blue and purple) captured in a nano-size pore of an MFM-520 metal-organic framework material as observed using neutron vibrational spectroscopy at Oak Ridge National Laboratory. Image credit: ORNL/Jill Hemman

An international team of scientists, led by the University of Manchester, has developed a metal-organic framework, or MOF, material

Elizabeth Herndon takes a soil sample at a field site outside Abisko, Sweden in July 2019.

Elizabeth Herndon believes in going the distance whether she is preparing to compete in the 2020 Olympic marathon trials or examining how metals move through the environment as a geochemist at the Department of Energy’s Oak Ridge National Laboratory.

CellSight allows for rapid mass spectrometry of individual cells. Credit: John Cahill, Oak Ridge National Laboratory/U.S. Dept of Energy

Researchers at the Department of Energy’s Oak Ridge National Laboratory have received five 2019 R&D 100 Awards, increasing the lab’s total to 221 since the award’s inception in 1963.

Water and energy are inextricably linked, yet in our 20th-century water systems we use freshwater once then throw it away. With innovations designed to enhance desalination technologies, agricultural runoff, produced water from industry, and inland brackish groundwater that are now seen as untreatable could all be sources of clean, safe, and affordable water.

The National Alliance for Water Innovation, a partnership of the Department of Energy’s Oak Ridge National Laboratory, other national labs, university and private sector partners, has been awarded a five-year, $100 million Energy-Water Desalination Hub by DOE to address water security issues in the United States.

Electro-Active Tech license signing ceremony

Electro-Active Technologies, Inc., of Knoxville, Tenn., has exclusively licensed two biorefinery technologies invented and patented by the startup’s co-founders while working at the Department of Energy’s Oak Ridge National Laboratory. The technologies work as a system that converts organic waste into renewable hydrogen gas for use as a biofuel.

Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL

OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.