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Gobet_Advincula Portrait

Polymer expert Advincula named ORNL-UT Governor’s Chair

Rigoberto “Gobet” Advincula has been named Governor’s Chair of Advanced and Nanostructured Materials at Oak Ridge National Laboratory and the University of Tennessee.

Scanning probe microscopes use an atom-sharp tip—only a few nanometers thick—to image materials on a nanometer length scale. The probe tip, invisible to the eye, is attached to a cantilever (pictured) that moves across material surfaces like the tone arm on a record player. Credit: Genevieve Martin/Oak Ridge National Laboratory; U.S. Dept. of Energy.

Liam Collins: Mapping the unseen

Liam Collins was drawn to study physics to understand “hidden things” and honed his expertise in microscopy so that he could bring them to light.

Liane Russell

“A life well lived:” Symposium honors research legacy of Liane Russell

A select group gathered on the morning of Dec. 20 at the Department of Energy’s Oak Ridge National Laboratory for a symposium in honor of Liane B. Russell, the renowned ORNL mammalian geneticist who died in July.

The students analyzed diatom images like this one to compare wild and genetically modified strains of these organisms. Credit: Alison Pawlicki/Oak Ridge National Laboratory, US Department of Energy.

High school students’ data science contributions boost biomineralization research

Students often participate in internships and receive formal training in their chosen career fields during college, but some pursue professional development opportunities even earlier.

Researchers at the Center for Nanophase Materials Sciences demonstrated an insect-inspired, mechanical gyroscope to advance motion sensing capabilities in consumer-sized applications. Credit: Jill Hemman/Oak Ridge National Laboratory, U.S Dept. of Energy

Nanoscience—Insect-inspired motion sensing

Researchers at ORNL and the National Renewable Energy Laboratory took inspiration from flying insects to demonstrate a miniaturized gyroscope, a special sensor used in navigation technologies. 

Desalination process

Clean water—Sunny desalination

A new method developed at Oak Ridge National Laboratory improves the energy efficiency of a desalination process known as solar-thermal evaporation. 

Molecular dynamics simulations of the Fs-peptide revealed the presence of at least eight distinct intermediate stages during the process of protein folding. The image depicts a fully folded helix (1), various transitional forms (2–8), and one misfolded state (9). By studying these protein folding pathways, scientists hope to identify underlying factors that affect human health.

Modified deep-learning algorithms unveil features of shape-shifting proteins

Using artificial neural networks designed to emulate the inner workings of the human brain, deep-learning algorithms deftly peruse and analyze large quantities of data. Applying this technique to science problems can help unearth historically elusive solutions.

Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL

Neutrons paint atomic portrait of prototypical cell signaling enzyme

OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.

Neutron scattering allowed direct observation of how aurein induces lateral segregation in the bacteria membranes, which creates instability in the membrane structure. This instability causes the membranes to fail, making harmful bacteria less effective.

Neutrons—Fighting superbugs

As the rise of antibiotic-resistant bacteria known as superbugs threatens public health, Oak Ridge National Laboratory’s Shuo Qian and Veerendra Sharma from the Bhaba Atomic Research Centre in India are using neutron scattering to study how an antibacterial peptide interacts with and fights harmful bacteria.

(From left) ORNL Associate Laboratory Director for Computing and Computational Sciences Jeff Nichols; ORNL Health Data Sciences Institute Director Gina Tourassi; DOE Deputy Under Secretary for Science Thomas Cubbage; ORNL Task Lead for Biostatistics Blair Christian; and ORNL Research Scientist Ioana Danciu were invited to the White House to showcase an ORNL-developed digital tool aimed at better matching cancer patients with clinical trials.

New ORNL AI tool revolutionizes process for matching cancer patients with clinical trials

OAK RIDGE, Tenn., March 4, 2019—A team of researchers from the Department of Energy’s Oak Ridge National Laboratory Health Data Sciences Institute have harnessed the power of artificial intelligence to better match cancer patients with clinical trials.