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Media Contacts
![Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL](/sites/default/files/styles/list_page_thumbnail/public/2019-03/19-G00204_MR_graphic_Kovalevsky_proof5_2.png?h=b7fbb1a9&itok=wrZFNX-o)
OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.
![Neutron scattering allowed direct observation of how aurein induces lateral segregation in the bacteria membranes, which creates instability in the membrane structure. This instability causes the membranes to fail, making harmful bacteria less effective.](/sites/default/files/styles/list_page_thumbnail/public/2019-03/Neutrons-FightingSuperbugs_0.jpg?h=e4b73f5a&itok=ebOQD-Mr)
As the rise of antibiotic-resistant bacteria known as superbugs threatens public health, Oak Ridge National Laboratory’s Shuo Qian and Veerendra Sharma from the Bhaba Atomic Research Centre in India are using neutron scattering to study how an antibacterial peptide interacts with and fights harmful bacteria.
![18-G01703 PinchPoint-v2.jpg 18-G01703 PinchPoint-v2.jpg](/sites/default/files/styles/list_page_thumbnail/public/18-G01703%20PinchPoint-v2.jpg?itok=paJUPDI1)
Researchers used neutron scattering at Oak Ridge National Laboratory’s Spallation Neutron Source to investigate bizarre magnetic behavior, believed to be a possible quantum spin liquid rarely found in a three-dimensional material. QSLs are exotic states of matter where magnetism continues to fluctuate at low temperatures instead of “freezing” into aligned north and south poles as with traditional magnets.
![Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing. Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing.](/sites/default/files/styles/list_page_thumbnail/public/2018-P09551.jpg?itok=q7Ri01Qb)
Scientists at the Department of Energy’s Oak Ridge National Laboratory have created a recipe for a renewable 3D printing feedstock that could spur a profitable new use for an intractable biorefinery byproduct: lignin.
![2018-P07635 BL-6 user - Univ of Guelph-6004R_sm[2].jpg 2018-P07635 BL-6 user - Univ of Guelph-6004R_sm[2].jpg](/sites/default/files/styles/list_page_thumbnail/public/2018-P07635%20BL-6%20user%20-%20Univ%20of%20Guelph-6004R_sm%5B2%5D.jpg?itok=DUdZNt_q)
A team of scientists, led by University of Guelph professor John Dutcher, are using neutrons at ORNL’s Spallation Neutron Source to unlock the secrets of natural nanoparticles that could be used to improve medicines.
![Researchers 3D printed molds for precasting concrete using the Big Area Additive Manufacturing, or BAAM™, system at DOE’s Manufacturing Demonstration Facility at ORNL. Complex, durable mold designs can be produced in less time than traditional wood or fib Researchers 3D printed molds for precasting concrete using the Big Area Additive Manufacturing, or BAAM™, system at DOE’s Manufacturing Demonstration Facility at ORNL. Complex, durable mold designs can be produced in less time than traditional wood or fib](/sites/default/files/styles/list_page_thumbnail/public/news/images/02%20-%203D-printed_precast_concrete_molds.gif?itok=nni1l9l2)
The construction industry may soon benefit from 3D printed molds to make concrete facades, promising lower cost and production time. Researchers at Oak Ridge National Laboratory are evaluating the performance of 3D printed molds used to precast concrete facades in a 42-story buildin...
![3D printed permanent magnets with increased density were made from an improved mixture of materials, which could lead to longer lasting, better performing magnets for electric motors, sensors and vehicle applications. Credit: Jason Richards/Oak Ridge Nati 3D printed permanent magnets with increased density were made from an improved mixture of materials, which could lead to longer lasting, better performing magnets for electric motors, sensors and vehicle applications. Credit: Jason Richards/Oak Ridge Nati](/sites/default/files/styles/list_page_thumbnail/public/news/images/06%20-%203D-printed_permament_magnet.jpg?itok=q28pGVEm)
Oak Ridge National Laboratory scientists have improved a mixture of materials used to 3D print permanent magnets with increased density, which could yield longer lasting, better performing magnets for electric motors, sensors and vehicle applications. Building on previous research, ...
![Radiochemical technicians David Denton and Karen Murphy use hot cell manipulators at Oak Ridge National Laboratory during the production of actinium-227. Radiochemical technicians David Denton and Karen Murphy use hot cell manipulators at Oak Ridge National Laboratory during the production of actinium-227.](/sites/default/files/styles/list_page_thumbnail/public/2016-P07827%5B1%5D.jpg?itok=yJbnFQLU)
The Department of Energy’s Oak Ridge National Laboratory is now producing actinium-227 (Ac-227) to meet projected demand for a highly effective cancer drug through a 10-year contract between the U.S. DOE Isotope Program and Bayer.
![Oak Ridge National Laboratory researcher Halil Tekinalp combines silanes and polylactic acid to create supertough renewable plastic. Oak Ridge National Laboratory researcher Halil Tekinalp combines silanes and polylactic acid to create supertough renewable plastic.](/sites/default/files/styles/list_page_thumbnail/public/news/images/02%20Materials-Supertough_bioplastic.jpg?itok=64jAyN8y)
A novel method developed at Oak Ridge National Laboratory creates supertough renewable plastic with improved manufacturability. Working with polylactic acid, a biobased plastic often used in packaging, textiles, biomedical implants and 3D printing, the research team added tiny amo...
![This isotropic, neodymium-iron-boron bonded permanent magnet was 3D-printed at DOE’s Manufacturing Demonstration Facility at Oak Ridge National Laboratory. This isotropic, neodymium-iron-boron bonded permanent magnet was 3D-printed at DOE’s Manufacturing Demonstration Facility at Oak Ridge National Laboratory.](/sites/default/files/styles/list_page_thumbnail/public/3Dprintedmagnet_image1_0.jpg?itok=uHDlDr_T)
Researchers at the Department of Energy’s Oak Ridge National Laboratory have demonstrated that permanent magnets produced by additive manufacturing can outperform bonded magnets made using traditional techniques while conserving critical materials. Scientists fabric...