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Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL

OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.

Neutron scattering allowed direct observation of how aurein induces lateral segregation in the bacteria membranes, which creates instability in the membrane structure. This instability causes the membranes to fail, making harmful bacteria less effective.

As the rise of antibiotic-resistant bacteria known as superbugs threatens public health, Oak Ridge National Laboratory’s Shuo Qian and Veerendra Sharma from the Bhaba Atomic Research Centre in India are using neutron scattering to study how an antibacterial peptide interacts with and fights harmful bacteria.

In this MXene electrode, choosing the appropriate solvent for the electrolyte can increase energy density significantly. This scanning electron microscopy image shows fine features of a film only 5 microns thick—approximately 10 times narrower than a human hair. Credit: Drexel University; image by Tyler Mathis
Scientists at ORNL, Drexel University and their partners have discovered a way to improve the energy density of promising energy-storage materials, conductive two-dimensional ceramics called MXenes.
ORNL astrophysicist Raph Hix models the inner workings of supernovae on the world’s most powerful supercomputers.

More than 1800 years ago, Chinese astronomers puzzled over the sudden appearance of a bright “guest star” in the sky, unaware that they were witnessing the cosmic forge of a supernova, an event repeated countless times scattered across the universe.

Researchers analyzed the oxygen structure (highlighted in red) found in a perovskite’s crystal structure at room temperature, 500°C and 900°C using neutron scattering at ORNL’s Spallation Neutron Source. Analyzing how these structures impact solid oxide f

A University of South Carolina research team is investigating the oxygen reduction performance of energy conversion materials called perovskites by using neutron diffraction at Oak Ridge National Laboratory’s Spallation Neutron Source.

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OAK RIDGE, Tenn., Jan. 31, 2019—A new electron microscopy technique that detects the subtle changes in the weight of proteins at the nanoscale—while keeping the sample intact—could open a new pathway for deeper, more comprehensive studies of the basic building blocks of life. 

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Oak Ridge National Laboratory scientists studying fuel cells as a potential alternative to internal combustion engines used sophisticated electron microscopy to investigate the benefits of replacing high-cost platinum with a lower cost, carbon-nitrogen-manganese-based catalyst.

COHERENT collaborators were the first to observe coherent elastic neutrino–nucleus scattering. Their results, published in the journal Science, confirm a prediction of the Standard Model and establish constraints on alternative theoretical models. Image c

After more than a year of operation at the Department of Energy’s (DOE’s) Oak Ridge National Laboratory (ORNL), the COHERENT experiment, using the world’s smallest neutrino detector, has found a big fingerprint of the elusive, electrically neutral particles that interact only weakly with matter.

ORNL’s Xiahan Sang unambiguously resolved the atomic structure of MXene, a 2D material promising for energy storage, catalysis and electronic conductivity. Image credit: Oak Ridge National Laboratory, U.S. Dept. of Energy; photographer Carlos Jones

Researchers have long sought electrically conductive materials for economical energy-storage devices. Two-dimensional (2D) ceramics called MXenes are contenders. Unlike most 2D ceramics, MXenes have inherently good conductivity because they are molecular sheets made from the carbides ...

This isotropic, neodymium-iron-boron bonded permanent magnet was 3D-printed at DOE’s Manufacturing Demonstration Facility at Oak Ridge National Laboratory.

Researchers at the Department of Energy’s Oak Ridge National Laboratory have demonstrated that permanent magnets produced by additive manufacturing can outperform bonded magnets made using traditional techniques while conserving critical materials. Scientists fabric...