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Media Contacts
![Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL](/sites/default/files/styles/list_page_thumbnail/public/2019-03/19-G00204_MR_graphic_Kovalevsky_proof5_2.png?h=b7fbb1a9&itok=wrZFNX-o)
OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.
![Neutron scattering allowed direct observation of how aurein induces lateral segregation in the bacteria membranes, which creates instability in the membrane structure. This instability causes the membranes to fail, making harmful bacteria less effective.](/sites/default/files/styles/list_page_thumbnail/public/2019-03/Neutrons-FightingSuperbugs_0.jpg?h=e4b73f5a&itok=ebOQD-Mr)
As the rise of antibiotic-resistant bacteria known as superbugs threatens public health, Oak Ridge National Laboratory’s Shuo Qian and Veerendra Sharma from the Bhaba Atomic Research Centre in India are using neutron scattering to study how an antibacterial peptide interacts with and fights harmful bacteria.
![Nuclear—Deep space travel Nuclear—Deep space travel](/sites/default/files/styles/list_page_thumbnail/public/Screen%20Shot%202018-12-19%20at%2010.29.32%20AM.png?itok=hq0dlVIf)
By automating the production of neptunium oxide-aluminum pellets, Oak Ridge National Laboratory scientists have eliminated a key bottleneck when producing plutonium-238 used by NASA to fuel deep space exploration.
![Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing. Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing.](/sites/default/files/styles/list_page_thumbnail/public/2018-P09551.jpg?itok=q7Ri01Qb)
Scientists at the Department of Energy’s Oak Ridge National Laboratory have created a recipe for a renewable 3D printing feedstock that could spur a profitable new use for an intractable biorefinery byproduct: lignin.
![2018-P07635 BL-6 user - Univ of Guelph-6004R_sm[2].jpg 2018-P07635 BL-6 user - Univ of Guelph-6004R_sm[2].jpg](/sites/default/files/styles/list_page_thumbnail/public/2018-P07635%20BL-6%20user%20-%20Univ%20of%20Guelph-6004R_sm%5B2%5D.jpg?itok=DUdZNt_q)
A team of scientists, led by University of Guelph professor John Dutcher, are using neutrons at ORNL’s Spallation Neutron Source to unlock the secrets of natural nanoparticles that could be used to improve medicines.
![exp_in_10_dry_tube.jpg exp_in_10_dry_tube.jpg](/sites/default/files/styles/list_page_thumbnail/public/exp_in_10_dry_tube.jpg?itok=cmBuu2CQ)
Scientists from Oak Ridge National Laboratory performed a corrosion test in a neutron radiation field to support the continued development of molten salt reactors.
![ORNL is again hosting a workshop focused on the next generation of molten salt reactors. ORNL is again hosting a workshop focused on the next generation of molten salt reactors.](/sites/default/files/styles/list_page_thumbnail/public/news/images/05%20-%20NUCLEAR_Molten_Salt_Reactor_Workshop.jpg?itok=5mV4FIMW)
Experts focused on the future of nuclear technology will gather at Oak Ridge National Laboratory for the fourth annual Molten Salt Reactor Workshop on October 3–4.
![Radiochemical technicians David Denton and Karen Murphy use hot cell manipulators at Oak Ridge National Laboratory during the production of actinium-227. Radiochemical technicians David Denton and Karen Murphy use hot cell manipulators at Oak Ridge National Laboratory during the production of actinium-227.](/sites/default/files/styles/list_page_thumbnail/public/2016-P07827%5B1%5D.jpg?itok=yJbnFQLU)
The Department of Energy’s Oak Ridge National Laboratory is now producing actinium-227 (Ac-227) to meet projected demand for a highly effective cancer drug through a 10-year contract between the U.S. DOE Isotope Program and Bayer.
![Kevin Robb, a staff scientist at the Department of Energy’s Oak Ridge National Laboratory, is taking what he learned from developing the Liquid Salt Test Loop—a key tool in deploying molten salt technology applications Kevin Robb, a staff scientist at the Department of Energy’s Oak Ridge National Laboratory, is taking what he learned from developing the Liquid Salt Test Loop—a key tool in deploying molten salt technology applications](/sites/default/files/styles/list_page_thumbnail/public/news/images/2017-P03818_1.jpg?itok=qQLLL9dH)
Thanks in large part to developing and operating a facility for testing molten salt reactor (MSR) technologies, nuclear experts at the Energy Department’s Oak Ridge National Laboratory (ORNL) are now tackling the next generation of another type of clean energy—concentrating ...
![By producing 50 grams of plutonium-238, Oak Ridge National Laboratory researchers have demonstrated the nation’s ability to provide a valuable energy source for deep space missions. By producing 50 grams of plutonium-238, Oak Ridge National Laboratory researchers have demonstrated the nation’s ability to provide a valuable energy source for deep space missions.](/sites/default/files/styles/list_page_thumbnail/public/front_page_slide_assets/2015-P07524.jpg?itok=MEy22Na3)
With the production of 50 grams of plutonium-238, researchers at the Department of Energy’s Oak Ridge National Laboratory have restored a U.S. capability dormant for nearly 30 years and set the course to provide power for NASA and other missions.