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Media Contacts
![Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL](/sites/default/files/styles/list_page_thumbnail/public/2019-03/19-G00204_MR_graphic_Kovalevsky_proof5_2.png?h=b7fbb1a9&itok=wrZFNX-o)
OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.
![Oak Ridge National Laboratory entrance sign](/themes/custom/ornl/images/default-thumbnail.jpg)
The unique process of accepting a new supercomputer is one of the most challenging projects a programmer may take on during a career. When the Oak Ridge Leadership Computing Facility’s (OLCF’s) Verónica Melesse Vergara came to the United States from Ecuador in 2005, she never would have dreamed of being part of such an endeavor. But just last fall, she was.
![(From left) ORNL Associate Laboratory Director for Computing and Computational Sciences Jeff Nichols; ORNL Health Data Sciences Institute Director Gina Tourassi; DOE Deputy Under Secretary for Science Thomas Cubbage; ORNL Task Lead for Biostatistics Blair Christian; and ORNL Research Scientist Ioana Danciu were invited to the White House to showcase an ORNL-developed digital tool aimed at better matching cancer patients with clinical trials.](/sites/default/files/styles/list_page_thumbnail/public/2019-03/TourassiWH%5B1%5D.png?h=26b5064d&itok=HUC2iYmE)
OAK RIDGE, Tenn., March 4, 2019—A team of researchers from the Department of Energy’s Oak Ridge National Laboratory Health Data Sciences Institute have harnessed the power of artificial intelligence to better match cancer patients with clinical trials.
![The Consortium for Advanced Simulation of Light Water Reactors uses its Virtual Environment for Reactor Applications (VERA) software for the modeling and simulation of various nuclear reactors, such as the Westinghouse AP1000 pressurized water reactor. The Consortium for Advanced Simulation of Light Water Reactors uses its Virtual Environment for Reactor Applications (VERA) software for the modeling and simulation of various nuclear reactors, such as the Westinghouse AP1000 pressurized water reactor.](/sites/default/files/styles/list_page_thumbnail/public/AP1000_highres_pin_powers.png?itok=5jd5vcFM)
The Department of Energy’s Oak Ridge National Laboratory is collaborating with industry on six new projects focused on advancing commercial nuclear energy technologies that offer potential improvements to current nuclear reactors and move new reactor designs closer to deployment.
![Clarice Phelps Clarice Phelps](/sites/default/files/styles/list_page_thumbnail/public/Clarice%20Phelps.00_01_06_10.Still003.jpg?itok=ZA8iTcAk)
More than 70 years ago, United States Navy Captain Hyman Rickover learned the ins and outs of nuclear science and reactor technology at the Clinton Training School at what would eventually become the Department of Energy’s Oak Ridge National Laboratory. Rickover applied his knowl...
![Two neutron diffraction experiments (represented by pink and blue neutron beams) probed a salty solution to reveal its atomic structure. The only difference between the experiments was the identity of the oxygen isotope (O*) that labeled nitrate molecules Two neutron diffraction experiments (represented by pink and blue neutron beams) probed a salty solution to reveal its atomic structure. The only difference between the experiments was the identity of the oxygen isotope (O*) that labeled nitrate molecules](/sites/default/files/styles/list_page_thumbnail/public/news/images/ORNL%202018-G01254-AM-01.jpg?itok=WXkmqIs1)
Scientists at the Department of Energy’s Oak Ridge National Laboratory used neutrons, isotopes and simulations to “see” the atomic structure of a saturated solution and found evidence supporting one of two competing hypotheses about how ions come
![Default image of ORNL entry sign](/sites/default/files/styles/list_page_thumbnail/public/2023-09/default-thumbnail.jpg?h=553c93cc&itok=N_Kd1DVR)
If you ask the staff and researchers at the Department of Energy’s Oak Ridge National Laboratory how they were first referred to the lab, you will get an extremely varied list of responses. Some may have come here as student interns, some grew up in the area and knew the lab by ...
![Oak Ridge National Laboratory has signed a memorandum of understanding with the United Kingdom’s National Nuclear Laboratory to partner on various nuclear research and development efforts. Oak Ridge National Laboratory has signed a memorandum of understanding with the United Kingdom’s National Nuclear Laboratory to partner on various nuclear research and development efforts.](/sites/default/files/styles/list_page_thumbnail/public/NNL_MainImage.jpg?itok=8cSrtngA)
The United Kingdom’s National Nuclear Laboratory and the U.S. Department of Energy’s Oak Ridge National Laboratory have agreed to cooperate on a wide range of nuclear energy research and development efforts that leverage both organizations’ unique expertise and capabilities.
![QRNG_photo_ORNL.png QRNG_photo_ORNL.png](/sites/default/files/styles/list_page_thumbnail/public/QRNG_photo_ORNL.png?itok=-avZ0m1m)
Qrypt, Inc., has exclusively licensed a novel cyber security technology from the Department of Energy’s Oak Ridge National Laboratory, promising a stronger defense against cyberattacks including those posed by quantum computing.
![Oak Ridge National Laboratory’s Summit supercomputer was named No. 1 on the TOP500 List, a semiannual ranking of the world’s fastest computing systems. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy.Oak Ridge National Laboratory’ Oak Ridge National Laboratory’s Summit supercomputer was named No. 1 on the TOP500 List, a semiannual ranking of the world’s fastest computing systems. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy.](/sites/default/files/styles/list_page_thumbnail/public/2018-P03971.jpg?itok=BNeaoWKB)
The US Department of Energy’s Oak Ridge National Laboratory is once again officially home to the fastest supercomputer in the world, according to the TOP500 List, a semiannual ranking of the world’s fastest computing systems.