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Molecular dynamics simulations of the Fs-peptide revealed the presence of at least eight distinct intermediate stages during the process of protein folding. The image depicts a fully folded helix (1), various transitional forms (2–8), and one misfolded state (9). By studying these protein folding pathways, scientists hope to identify underlying factors that affect human health.

Using artificial neural networks designed to emulate the inner workings of the human brain, deep-learning algorithms deftly peruse and analyze large quantities of data. Applying this technique to science problems can help unearth historically elusive solutions.

To develop complex materials with superior properties, Vera Bocharova uses diverse methods including broadband dielectric spectroscopy. Credit: Oak Ridge National Laboratory, U.S. Dept. of Energy; photographer Jason Richards

Vera Bocharova at the Department of Energy’s Oak Ridge National Laboratory investigates the structure and dynamics of soft materials—polymer nanocomposites, polymer electrolytes and biological macromolecules—to advance materials and technologies for energy, medicine and other applications.

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While studying the genes in poplar trees that control callus formation, scientists at Oak Ridge National Laboratory have uncovered genetic networks at the root of tumor formation in several human cancers.

From left, Amit Naskar, Ngoc Nguyen and Christopher Bowland in ORNL’s Carbon and Composites Group bring a new capability—structural health monitoring—to strong, lightweight materials promising for transportation applications.

Carbon fiber composites—lightweight and strong—are great structural materials for automobiles, aircraft and other transportation vehicles. They consist of a polymer matrix, such as epoxy, into which reinforcing carbon fibers have been embedded. Because of differences in the mecha...

Sergei Kalinin, director of the Institute for Functional Imaging of Materials at Oak Ridge National Laboratory, convenes experts in microscopy and computing to gain scientific insights that will inform design of advanced materials for energy and informati

Sergei Kalinin of the Department of Energy’s Oak Ridge National Laboratory knows that seeing something is not the same as understanding it. As director of ORNL’s Institute for Functional Imaging of Materials, he convenes experts in microscopy and computing to gain scientific insigh...

Schematic drawing of the boron nitride cell. Credit: University of Illinois at Chicago.

A new microscopy technique developed at the University of Illinois at Chicago allows researchers to visualize liquids at the nanoscale level — about 10 times more resolution than with traditional transmission electron microscopy — for the first time. By trapping minute amounts of...

Kevin Robb, a staff scientist at the Department of Energy’s Oak Ridge National Laboratory, is taking what he learned from developing the Liquid Salt Test Loop—a key tool in deploying molten salt technology applications

Thanks in large part to developing and operating a facility for testing molten salt reactor (MSR) technologies, nuclear experts at the Energy Department’s Oak Ridge National Laboratory (ORNL) are now tackling the next generation of another type of clean energy—concentrating ...

Composites scientist and engineer Vlastimil Kunc with the latest large-scale 3Dprinter at the MDF.

Vlastimil Kunc grew up in a family of scientists where his natural curiosity was encouraged—an experience that continues to drive his research today in polymer composite additive manufacturing at Oak Ridge National Laboratory. “I’ve been interested in the science of composites si...

A senior research scientist at Oak Ridge National Laboratory, Olufemi “Femi” Omitaomu is leveraging Big Data for urban resilience. Image credit: Oak Ridge National Laboratory, U.S. Dept. of Energy; photographer Jason Richards.

At the Department of Energy’s Oak Ridge National Laboratory, Olufemi “Femi” Omitaomu is leveraging Big Data for urban resilience, helping growing cities support future infrastructure and resource needs. A senior research scientist for ORNL’s Computational Sciences and Engineeri...

ORNL researcher Miaofang Chi refines her microscopy techniques toward understanding how and why materials have certain properties.

Material surfaces and interfaces may appear flat and void of texture to the naked eye, but a view from the nanoscale reveals an intricate tapestry of atomic patterns that control the reactions between the material and its environment. Electron microscopy allows researchers to probe...