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Analyses of lung fluid cells from COVID-19 patients conducted on the nation’s fastest supercomputer point to gene expression patterns that may explain the runaway symptoms produced by the body’s response to SARS-CoV-2. Credit: Jason B. Smith/ORNL, U.S. Dept. of Energy

A team led by Dan Jacobson of Oak Ridge National Laboratory used the Summit supercomputer at ORNL to analyze genes from cells in the lung fluid of nine COVID-19 patients compared with 40 control patients.

The CrossVis application includes a parallel coordinates plot (left), a tiled image view (right) and other interactive data views. Credit: Chad Steed/Oak Ridge National Laboratory, U.S. Dept. of Energy

From materials science and earth system modeling to quantum information science and cybersecurity, experts in many fields run simulations and conduct experiments to collect the abundance of data necessary for scientific progress.

Sergei Kalinin

Five researchers at the Department of Energy’s Oak Ridge National Laboratory have been named ORNL Corporate Fellows in recognition of significant career accomplishments and continued leadership in their scientific fields.

An organic solvent and water separate and form nanoclusters on the hydrophobic and hydrophilic sections of plant material, driving the efficient deconstruction of biomass. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

Scientists at ORNL used neutron scattering and supercomputing to better understand how an organic solvent and water work together to break down plant biomass, creating a pathway to significantly improve the production of renewable

Colorized micrograph of lily pollen

Oak Ridge National Laboratory researchers have built a novel microscope that provides a “chemical lens” for viewing biological systems including cell membranes and biofilms.

The protease protein is both shaped like a heart and functions as one, allowing the virus replicate and spread. Inhibiting the protease would block virus reproduction. Credit: Andrey Kovalevsky/ORNL, U.S. Dept. of Energy

A team of researchers has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease — the enzyme that enables the virus to reproduce.

Yanwen Zhang

In the search to create materials that can withstand extreme radiation, Yanwen Zhang, a researcher at the Department of Energy’s Oak Ridge National Laboratory, says that materials scientists must think outside the box.

Computing – Mining for COVID-19 connections

Scientists have tapped the immense power of the Summit supercomputer at Oak Ridge National Laboratory to comb through millions of medical journal articles to identify potential vaccines, drugs and effective measures that could suppress or stop the

XACC enables the programming of quantum code alongside standard classical code and integrates quantum computers from a number of vendors. This animation illustrates how QPUs complete calculations and return results to the host CPU, a process that could drastically accelerate future scientific simulations. Credit: Michelle Lehman/Oak Ridge National Laboratory, U.S. Dept. of Energy

In the early 2000s, high-performance computing experts repurposed GPUs — common video game console components used to speed up image rendering and other time-consuming tasks 

Prospecting for deformations in exotic isotopes of ruthenium and molybdenum, Allmond found they displayed a deflated-football morphology. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy

In the Physics Division of the Department of Energy’s Oak Ridge National Laboratory, James (“Mitch”) Allmond conducts experiments and uses theoretical models to advance our understanding of the structure of atomic nuclei, which are made of various combinations of protons and neutrons (nucleons).