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Stephanie Galanie

Early career scientist Stephanie Galanie has applied her expertise in synthetic biology to a number of challenges in academia and private industry. She’s now bringing her skills in high-throughput bio- and analytical chemistry to accelerate research on feedstock crops as a Liane B. Russell Fellow at Oak Ridge National Laboratory.

Laccaria bicolor is fruiting aboveground and colonizing the Populus deltoides plant root system belowground in a greenhouse setting.

A team of scientists led by Oak Ridge National Laboratory have discovered the specific gene that controls an important symbiotic relationship between plants and soil fungi, and successfully facilitated the symbiosis in a plant that

Computing—Building a brain

Researchers at Oak Ridge National Laboratory are taking inspiration from neural networks to create computers that mimic the human brain—a quickly growing field known as neuromorphic computing.

Quantum—Widening the net

Scientists at Oak Ridge National Laboratory studying quantum communications have discovered a more practical way to share secret messages among three parties, which could ultimately lead to better cybersecurity for the electric grid 

Computing—Routing out the bugs

A study led by Oak Ridge National Laboratory explored the interface between the Department of Veterans Affairs’ healthcare data system and the data itself to detect the likelihood of errors and designed an auto-surveillance tool

ORNL collaborator Hsiu-Wen Wang led the neutron scattering experiments at the Spallation Neutron Source to probe complex electrolyte solutions that challenge nuclear waste processing at Hanford and other sites. Credit: Genevieve Martin/Oak Ridge National Laboratory, U.S. Dept. of Energy.

Researchers at the Department of Energy’s Oak Ridge National Laboratory, Pacific Northwest National Laboratory and Washington State University teamed up to investigate the complex dynamics of low-water liquids that challenge nuclear waste processing at federal cleanup sites.

Desalination diagram

A team of scientists led by Oak Ridge National Laboratory used carbon nanotubes to improve a desalination process that attracts and removes ionic compounds such as salt from water using charged electrodes.

Molecular dynamics simulations of the Fs-peptide revealed the presence of at least eight distinct intermediate stages during the process of protein folding. The image depicts a fully folded helix (1), various transitional forms (2–8), and one misfolded state (9). By studying these protein folding pathways, scientists hope to identify underlying factors that affect human health.

Using artificial neural networks designed to emulate the inner workings of the human brain, deep-learning algorithms deftly peruse and analyze large quantities of data. Applying this technique to science problems can help unearth historically elusive solutions.

Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL

OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.

Neutron scattering allowed direct observation of how aurein induces lateral segregation in the bacteria membranes, which creates instability in the membrane structure. This instability causes the membranes to fail, making harmful bacteria less effective.

As the rise of antibiotic-resistant bacteria known as superbugs threatens public health, Oak Ridge National Laboratory’s Shuo Qian and Veerendra Sharma from the Bhaba Atomic Research Centre in India are using neutron scattering to study how an antibacterial peptide interacts with and fights harmful bacteria.