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Samantha Peters co-designed and conducted experiments using ORNL’s high-performance mass spectrometry techniques to prove that bacteriophages deploy genetic code-switching to overwhelm and destroy host bacteria. Credit: Genevieve Martin, ORNL/U.S. Dept. of Energy

Scientists at ORNL have confirmed that bacteria-killing viruses called bacteriophages deploy a sneaky tactic when targeting their hosts: They use a standard genetic code when invading bacteria, then switch to an alternate code at later stages of

ORNL’s Adam Guss began adapting the SAGE gene editing tool to modify microbes in graduate school. Today, SAGE is rapidly accelerating the design of custom microbes for a variety of applications. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

A DNA editing tool adapted by Oak Ridge National Laboratory scientists makes engineering microbes for everything from bioenergy production to plastics recycling easier and faster.

Fungal geneticist Joanna Tannous is gaining a better understanding of the genetic processes behind fungal life to both combat plant disease and encourage beneficial processes like soil carbon storage. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Joanna Tannous has found the perfect organism to study to satisfy her deeply curious nature, her skills in biochemistry and genetics, and a drive to create solutions for a better world. The organism is a poorly understood life form that greatly influences its environment and is unique enough to deserve its own biological kingdom: fungi.

Oak Ridge National Laboratory’s Dave Weston works in a chamber at the DOE SPRUCE whole ecosystem experiment site in the peatlands of northern Minnesota. Credit: Kyle Pearson/ORNL, U.S. Dept. of Energy

A quest to understand how Sphagnum mosses facilitate the storage of vast amounts of carbon in peatlands led scientists to a surprising discovery: the plants have sex-based differences that appear to impact the carbon-storing process.

Computational systems biologists at ORNL worked with the U.S. Department of Veterans Affairs and other institutions to identify 139 locations across the human genome tied to risk factors for varicose veins, marking a first step in the development of new treatments. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

As part of a multi-institutional research project, scientists at ORNL leveraged their computational systems biology expertise and the largest, most diverse set of health data to date to explore the genetic basis of varicose veins.

Researchers observe T-shaped cluster drives lanthanide separation system during liquid-liquid extraction. Credit: Alex Ivanov/ORNL, U.S. Dept. of Energy

Researchers at ORNL zoomed in on molecules designed to recover critical materials via liquid-liquid extraction — a method used by industry to separate chemically similar elements.

Researchers captured atomic-level insights on the rare-earth mineral monazite to inform future design of flotation collector molecules, illustrated above, that can aid in the recovery of critical materials. Credit: Chad Malone/ORNL, U.S. Dept. of Energy

Critical Materials Institute researchers at Oak Ridge National Laboratory and Arizona State University studied the mineral monazite, an important source of rare-earth elements, to enhance methods of recovering critical materials for energy, defense and manufacturing applications.

Hybrid poplar trees such as these shown in an ORNL greenhouse were engineered with the REVEILLE1 gene to delay dormancy and produce more biomass. The research was led by the Center for Bioenergy Innovation at ORNL with the Joint Genome Institute, Brookhaven National Laboratory, the HudsonAlpha Institute for Biotechnology, the University of Connecticut and other partners. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

A team of scientists led by ORNL discovered the gene in agave that governs when the plant goes dormant and used it to create poplar trees that nearly doubled in size, increasing biomass yield for biofuels production

Erica Prates is using her skills as a computational systems biologist to link the smallest molecules to their impact on large ecosystems. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Erica Prates has found a way to help speed the pursuit of healthier ecosystems by linking the function of the smallest molecules to their effects on large-scale processes, leveraging a combination of science, math and computing.

Seven scientists at the Department of Energy’s Oak Ridge National Laboratory have been named Battelle Distinguished Inventors, in recognition of their obtaining 14 or more patents during their careers at the lab. Credit: ORNL, U.S. Dept. of Energy

Seven scientists at the Department of Energy’s Oak Ridge National Laboratory have been named Battelle Distinguished Inventors, in recognition of their obtaining 14 or more patents during their careers at the lab.