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Media Contacts
![Neutron scattering experiments show electric charges, shown in red, blue and grey, in the SARS-CoV-2 main protease site where telaprevir binds to the structure. The experiments provide critical data for the design of small-molecule drugs to treat COVID-19. Credit: Jill Hemman and Michelle Lehman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2021-03/after_transprent_background-wFill.png?h=c71d0c67&itok=jGFt_Ggj)
Scientists have found new, unexpected behaviors when SARS-CoV-2 – the virus that causes COVID-19 – encounters drugs known as inhibitors, which bind to certain components of the virus and block its ability to reproduce.
![ORNL is designing a neutronic research engine to evaluate new materials and designs for advanced vehicles using the facilities at the Spallation Neutron Source at ORNL. Credit: Jill Hemman/ORNL, U.S. Dept of Energy, and Southwest Research Institute.](/sites/default/files/styles/list_page_thumbnail/public/2020-12/20-G01771_VULCAN_engine_proof1.png?h=e4fbc3eb&itok=f6owlGkE)
In the quest for advanced vehicles with higher energy efficiency and ultra-low emissions, ORNL researchers are accelerating a research engine that gives scientists and engineers an unprecedented view inside the atomic-level workings of combustion engines in real time.
![Diverse evidence shows that plants and soil will likely capture and hold more carbon in response to increasing levels of carbon dioxide in the atmosphere, according to an analysis published by an international research team led by Oak Ridge National Laboratory.](/sites/default/files/styles/list_page_thumbnail/public/2020-12/Climate%20%E2%80%93%20Global%20change%20analyses.jpg?h=468b42ad&itok=lhTGb-s4)
![An organic solvent and water separate and form nanoclusters on the hydrophobic and hydrophilic sections of plant material, driving the efficient deconstruction of biomass. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-11/dark_image_small.png?h=2e111cc1&itok=drKqW05b)
Experiments led by researchers at ORNL have determined that several hepatitis C drugs can inhibit the SARS-CoV-2 main protease, a crucial protein enzyme that enables the novel coronavirus to reproduce.
![The first neutron structure of the SARS-CoV-2 main protease enzyme revealed unexpected electrical charges in the amino acids cysteine (negative) and histidine (positive), providing key data about the virus’s replication. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-10/20-G01620_Protease_PR_proof2_0.jpg?h=3e3883a3&itok=XB_ZEDFQ)
To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.
![Sarah Cousineau](/sites/default/files/styles/list_page_thumbnail/public/2020-10/2019-P00901%20%281%29.jpg?h=c6980913&itok=TetsY0iB)
Two scientists with the Department of Energy’s Oak Ridge National Laboratory have been elected fellows of the American Physical Society.
![Substituting deuterium for hydrogen makes methylammonium heavier and slows its swaying so it can interact with vibrations that remove heat, keeping charge carriers hot longer. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-10/20-G00933_PR_Manley_0.jpg?h=eca34813&itok=3DjqguYT)
Led by ORNL and the University of Tennessee, Knoxville, a study of a solar-energy material with a bright future revealed a way to slow phonons, the waves that transport heat.
![Researcher Chase Joslin uses Peregrine software to monitor and analyze a component being 3D printed at the Manufacturing Demonstration Facility at ORNL. Credit: Luke Scime/ORNL, U.S. Dept. of Energy.](/sites/default/files/styles/list_page_thumbnail/public/2020-08/Peregrine%20Chase%20Joslin_0.jpg?h=51c7b451&itok=4Hc6PNwu)
Oak Ridge National Laboratory researchers have developed artificial intelligence software for powder bed 3D printers that assesses the quality of parts in real time, without the need for expensive characterization equipment.
![Sergei Kalinin](/sites/default/files/styles/list_page_thumbnail/public/2020-07/2019-P00126_0.png?h=5969a3b5&itok=66cucDCt)
Five researchers at the Department of Energy’s Oak Ridge National Laboratory have been named ORNL Corporate Fellows in recognition of significant career accomplishments and continued leadership in their scientific fields.
![An organic solvent and water separate and form nanoclusters on the hydrophobic and hydrophilic sections of plant material, driving the efficient deconstruction of biomass. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-07/THF_high_res.gif?h=5a472534&itok=5peedFnF)
Scientists at ORNL used neutron scattering and supercomputing to better understand how an organic solvent and water work together to break down plant biomass, creating a pathway to significantly improve the production of renewable