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ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.

Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

Solar panels funded by the Honnold Foundation are installed in Adjuntas, Puerto Rico. Credit: Fabio Andrade

When Hurricane Maria battered Puerto Rico in 2017, winds snapped trees and destroyed homes, while heavy rains transformed streets into rivers. But after the storm passed, the human toll continued to grow as residents struggled without electricity for months. Five years later, power outages remain long and frequent.

An artist's rendering of the Ultium Cells battery cell production facility to be built in Spring Hill, Tennessee, which will employ 1,300 people. Recognizing the unique expertise of their organizations, ORNL, TVA, and the Tennessee Department of Economic and Community Development have been working together for several years to bring startups developing battery technologies for EVs and established automotive firms to Tennessee. Credit: Ultium Cells

ORNL, TVA and TNECD were recognized by the Federal Laboratory Consortium for their impactful partnership that resulted in a record $2.3 billion investment by Ultium Cells, a General Motors and LG Energy Solution joint venture, to build a battery cell manufacturing plant in Spring Hill, Tennessee.

ORNL’s Marie Kurz examines the many factors affecting the health of streams and watersheds. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Spanning no less than three disciplines, Marie Kurz’s title — hydrogeochemist — already gives you a sense of the collaborative, interdisciplinary nature of her research at ORNL.

ORNL’s Brenda Pracheil, left, and Kristine Moody collect water samples at Melton Hill Lake using a sophisticated instrument that collects DNA in the water to determine fish species and number of fish in the water, which could prove useful for monitoring hydropower impacts. Credit: Carlos Jones, ORNL/U.S Dept. of Energy

Researchers at Oak Ridge National Laboratory are using a novel approach in determining environmental impacts to aquatic species near hydropower facilities, potentially leading to smarter facility designs that can support electrical grid reliability.

This protein drives key processes for sulfide use in many microorganisms that produce methane, including Thermosipho melanesiensis. Researchers used supercomputing and deep learning tools to predict its structure, which has eluded experimental methods such as crystallography.  Credit: Ada Sedova/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory and the Georgia Institute of Technology is using supercomputing and revolutionary deep learning tools to predict the structures and roles of thousands of proteins with unknown functions.

Researchers gained new insights into the mechanisms some methane-feeding bacteria called methanotrophs (pictured) use to break down the toxin methylmercury. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy; Jeremy Semrau/Univ. of Michigan

A team led by ORNL and the University of Michigan have discovered that certain bacteria can steal an essential compound from other microbes to break down methane and toxic methylmercury in the environment.

The Oak Ridge National Environmental Research Park encompasses a 20,000 acre area that includes Oak Ridge National Laboratory. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Anyone familiar with ORNL knows it’s a hub for world-class science. The nearly 33,000-acre space surrounding the lab is less known, but also unique.

As the leader of ORNL’s Biodiversity and Ecosystem Health Group, environmental scientist Teresa Mathews works to understand the impacts of energy generation on water and solve challenging problems, including mercury pollution. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Moving to landlocked Tennessee isn’t an obvious choice for most scientists with new doctorate degrees in coastal oceanography.