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ORNL’s Adam Guss began adapting the SAGE gene editing tool to modify microbes in graduate school. Today, SAGE is rapidly accelerating the design of custom microbes for a variety of applications. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

A DNA editing tool adapted by Oak Ridge National Laboratory scientists makes engineering microbes for everything from bioenergy production to plastics recycling easier and faster.

Technology to retrofit nonpowered dams such as the Lake Sequoyah Dam in North Carolina could be tested before deploying to ensure performance and reliability. Credit: Scott DeNeale/ORNL, U.S. Dept. of Energy

Researchers at Oak Ridge National Laboratory have identified a key need for future hydropower innovations – full-scale testing – to better inform developers and operators before making major investments.

ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.

Researchers at Oak Ridge National Laboratory probed the chemistry of radium to gain key insights on advancing cancer treatments using radiation therapy. Credit: Adam Malin/ORNL, U.S. Dept. of Energy

Researchers at ORNL explored radium’s chemistry to advance cancer treatments using ionizing radiation.

Melton Hill Dam

To further the potential benefits of the nation’s hydropower resources, researchers at Oak Ridge National Laboratory have developed and maintain a comprehensive water energy digital platform called HydroSource.

The AI-driven HyperCT platform has three primary points of articulation that can rotate a sample in almost any direction, eliminating the need for human intervention and significantly reducing lengthy experiment times. Credit: Genevieve Martin, ORNL/U.S. Dept. of Energy

Oak Ridge National Laboratory researchers are developing a first-of-its-kind artificial intelligence device for neutron scattering called Hyperspectral Computed Tomography, or HyperCT.

Oak Ridge National Laboratory researchers developed an invertible neural network, a type of artificial intelligence that mimics the human brain, to improve accuracy in climate-change models and predictions. Credit: Getty Images

Oak Ridge National Laboratory researchers developed an invertible neural network, a type of artificial intelligence that mimics the human brain, to improve accuracy in climate-change models and predictions.

Physicist Charles Havener uses the NASA end station at ORNL’s Multicharged Ion Research Facility to simulate the origin of X-ray emissions from space. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Scientists are using Oak Ridge National Laboratory’s Multicharged Ion Research Facility to simulate the cosmic origin of X-ray emissions resulting when highly charged ions collide with neutral atoms and molecules, such as helium and gaseous hydrogen.

A large generator is installed at the Meldahl hydropower plant in Kentucky. The energy sector anticipates longer lead times in procuring such large components for increasing construction and modernization of U.S. hydropower plants. Credit: American Municipal Power

A new Department of Energy report produced by Oak Ridge National Laboratory identifies several supply chain must-haves in maintaining the pivotal role hydropower will play in decarbonizing the nation’s grid.

The ORNL-developed AquaBOT measures a range of water quality indicators, providing data for studies focused on clean water and sustainable energy. Credit: Natalie Griffiths/ORNL, U.S. Dept. of Energy

Measuring water quality throughout river networks with precision, speed and at lower cost than traditional methods is now possible with AquaBOT, an aquatic drone developed by Oak Ridge National Laboratory.