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ORNL scientists developed a method that improves the accuracy of the CRISPR Cas9 gene editing tool used to modify microbes for renewable fuels and chemicals production. This research draws on the lab’s expertise in quantum biology, artificial intelligence and synthetic biology. Credit: Philip Gray/ORNL, U.S. Dept. of Energy

Scientists at ORNL used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.

ORNL’s Fernanda Santos examines a soil sample at an NGEE Arctic field site in the Alaskan tundra in June 2022. Credit: Amy Breen, University of Alaska Fairbanks.

Wildfires are an ancient force shaping the environment, but they have grown in frequency, range and intensity in response to a changing climate. At ORNL, scientists are working on several fronts to better understand and predict these events and what they mean for the carbon cycle and biodiversity.

ORNL scientists mutated amino acids in a receptor protein, shown in green, which diminished interaction with the SARS-CoV-2 virus spike protein, shown in red. Mutating the receptor protein hampered the virus’s ability to infect host cells. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

An illustration of the long-term evolution likely to occur as rising temperatures and subsequent thawing of frozen Arctic soils affects the northern Alaska tundra, as predicted by a high-performance model created by Oak Ridge National Laboratory. Credit: Adam Malin and Ethan Coon, ORNL/U.S. Dept. of Energy

Oak Ridge National Laboratory scientists set out to address one of the biggest uncertainties about how carbon-rich permafrost will respond to gradual sinking of the land surface as temperatures rise.

Jason Gardner, Sandra Davern and Peter Thornton have been elected fellows of AAAS. Credit: Laddy Fields/ORNL, U.S. Dept. of Energy

Three scientists from the Department of Energy’s Oak Ridge National Laboratory have been elected fellows of the American Association for the Advancement of Science, or AAAS.

ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.

A new process developed by Oak Ridge National Laboratory leverages deep learning techniques to study cell movements in a simulated environment, guided by simple physics rules similar to video-game play. Credit: MSKCC and UTK

Scientists have developed a novel approach to computationally infer previously undetected behaviors within complex biological environments by analyzing live, time-lapsed images that show the positioning of embryonic cells in C. elegans, or roundworms. Their published methods could be used to reveal hidden biological activity. 

Three ORNL scientists have been elected fellows of the American Association for the Advancement of Science, or AAAS, the world’s largest general scientific society and publisher of the Science family of journals. Credit: ORNL, U.S. Dept. of Energy

Three ORNL scientists have been elected fellows of the American Association for the Advancement of Science, or AAAS, the world’s largest general scientific society and publisher of the Science family of journals.

ORNL’s particle entanglement machine is a precursor to the device that researchers at the University of Oklahoma are building, which will produce entangled quantum particles for quantum sensing to detect underground pipeline leaks. Credit: ORNL, U.S. Dept. of Energy

To minimize potential damage from underground oil and gas leaks, Oak Ridge National Laboratory is co-developing a quantum sensing system to detect pipeline leaks more quickly.

The Department of Energy’s Office of Science has selected five Oak Ridge National Laboratory scientists for Early Career Research Program awards.

The Department of Energy’s Office of Science has selected five Oak Ridge National Laboratory scientists for Early Career Research Program awards.