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From left to right, Cortney Piper, executive director of the Tennessee Advanced Energy Business Council; Susan Hubbard, ORNL deputy for science and technology; Dan Miller, innovation Crossroads program lead; and Mike Paulus, ORNL director of technology transfer, attend the Innovation Crossroads Showcase at the Knoxville Chamber on Sept. 22. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

A crowd of investors and supporters turned out for last week’s Innovation Crossroads Showcase at the Knoxville Chamber as part of Innov865 Week. Sponsored by ORNL and the Tennessee Advanced Energy Business Council, the event celebrated deep-tech entrepreneurs and the Oak Ridge Corridor as a growing energy innovation hub for the nation.

Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

Scattering-type scanning near-field optical microscopy, a nondestructive technique in which the tip of the probe of a microscope scatters pulses of light to generate a picture of a sample, allowed the team to obtain insights into the composition of plant cell walls. Credit: Ali Passian/ORNL, U.S. Dept. of Energy

To optimize biomaterials for reliable, cost-effective paper production, building construction, and biofuel development, researchers often study the structure of plant cells using techniques such as freezing plant samples or placing them in a vacuum.

Jim Szybist, Propulsion Science section head at ORNL, is applying his years of alternative fuel combustion and thermodynamics research to the challenge of cleaning up the hard-to-decarbonize, heavy-duty mobility sector. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy.

What’s getting Jim Szybist fired up these days? It’s the opportunity to apply his years of alternative fuel combustion and thermodynamics research to the challenge of cleaning up the hard-to-decarbonize, heavy-duty mobility sector — from airplanes to locomotives to ships and massive farm combines.

ORNL, VA and Harvard researchers developed a sparse matrix full of anonymized information on what is thought to be the largest cohort of healthcare data used for this type of research in the U.S. The matrix can be probed with different methods, such as KESER, to gain new insights into human health. Credit: Nathan Armistead/ORNL, U.S. Dept. of Energy

A team of researchers has developed a novel, machine learning–based  technique to explore and identify relationships among medical concepts using electronic health record data across multiple healthcare providers.

Earth Day

Tackling the climate crisis and achieving an equitable clean energy future are among the biggest challenges of our time. 

David McCollum is bringing his interdisciplinary expertise in engineering, economics and policy to several initiatives at Oak Ridge National Laboratory in the global effort to transform energy systems equitably while respecting planetary boundaries. Credit: Lindsay McCollum

David McCollum is using his interdisciplinary expertise, international networks and boundless enthusiasm to lead Oak Ridge National Laboratory’s contributions to the Net Zero World initiative.

QLAN submit - A team from the U.S. Department of Energy’s Oak Ridge National Laboratory, Stanford University and Purdue University developed and demonstrated a novel, fully functional quantum local area network, or QLAN, to enable real-time adjustments to information shared with geographically isolated systems at ORNL using entangled photons passing through optical fiber. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

A rapidly emerging consensus in the scientific community predicts the future will be defined by humanity’s ability to exploit the laws of quantum mechanics.

An ORNL-led team studied the SARS-CoV-2 spike protein in the trimer state, shown here, to pinpoint structural transitions that could be disrupted to destabilize the protein and negate its harmful effects. Credit: Debsindhu Bhowmik/ORNL, U.S. Dept. of Energy

To explore the inner workings of severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, researchers from ORNL developed a novel technique.

The Energy Exascale Earth System Model project reliably simulates aspects of earth system variability and projects decadal changes that will critically impact the U.S. energy sector in the future. A new version of the model delivers twice the performance of its predecessor. Credit: E3SM, Dept. of Energy

A new version of the Energy Exascale Earth System Model, or E3SM, is two times faster than an earlier version released in 2018.