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Media Contacts
![Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL](/sites/default/files/styles/list_page_thumbnail/public/2019-03/19-G00204_MR_graphic_Kovalevsky_proof5_2.png?h=b7fbb1a9&itok=wrZFNX-o)
OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.
![Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing. Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing.](/sites/default/files/styles/list_page_thumbnail/public/2018-P09551.jpg?itok=q7Ri01Qb)
Scientists at the Department of Energy’s Oak Ridge National Laboratory have created a recipe for a renewable 3D printing feedstock that could spur a profitable new use for an intractable biorefinery byproduct: lignin.
![ORNL researchers Todd Toops, Charles Finney, and Melanie DeBusk (left to right) hold an example of a particulate filter used to collect harmful emissions in vehicles. ORNL researchers Todd Toops, Charles Finney, and Melanie DeBusk (left to right) hold an example of a particulate filter used to collect harmful emissions in vehicles.](/sites/default/files/styles/list_page_thumbnail/public/news/images/CG-1D%20user%20-%20ETSD_Toops-2878R_r1.jpg?itok=sRbVXIkF)
Researchers are looking to neutrons for new ways to save fuel during the operation of filters that clean the soot, or carbon and ash-based particulate matter, emitted by vehicles. A team of researchers from the Energy and Transportation Science Division at the Department of En...
![ORNL Image](/sites/default/files/styles/list_page_thumbnail/public/2017-S00094_2.jpg?itok=ZGWBnMOv)
Researchers used neutrons to probe a running engine at ORNL’s Spallation Neutron Source
![Vanadium atoms (blue) have unusually large thermal vibrations that stabilize the metallic state of a vanadium dioxide crystal. Red depicts oxygen atoms.](/sites/default/files/styles/list_page_thumbnail/public/2020-06/82289_web.jpg?h=05d1a54d&itok=_5hHRzzR)
For more than 50 years, scientists have debated what turns particular oxide insulators, in which electrons barely move, into metals, in which electrons flow freely.