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Media Contacts
![Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL](/sites/default/files/styles/list_page_thumbnail/public/2019-03/19-G00204_MR_graphic_Kovalevsky_proof5_2.png?h=b7fbb1a9&itok=wrZFNX-o)
OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.
![The Consortium for Advanced Simulation of Light Water Reactors uses its Virtual Environment for Reactor Applications (VERA) software for the modeling and simulation of various nuclear reactors, such as the Westinghouse AP1000 pressurized water reactor. The Consortium for Advanced Simulation of Light Water Reactors uses its Virtual Environment for Reactor Applications (VERA) software for the modeling and simulation of various nuclear reactors, such as the Westinghouse AP1000 pressurized water reactor.](/sites/default/files/styles/list_page_thumbnail/public/AP1000_highres_pin_powers.png?itok=5jd5vcFM)
The Department of Energy’s Oak Ridge National Laboratory is collaborating with industry on six new projects focused on advancing commercial nuclear energy technologies that offer potential improvements to current nuclear reactors and move new reactor designs closer to deployment.
![Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing. Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing.](/sites/default/files/styles/list_page_thumbnail/public/2018-P09551.jpg?itok=q7Ri01Qb)
Scientists at the Department of Energy’s Oak Ridge National Laboratory have created a recipe for a renewable 3D printing feedstock that could spur a profitable new use for an intractable biorefinery byproduct: lignin.
![Oak Ridge National Laboratory has signed a memorandum of understanding with the United Kingdom’s National Nuclear Laboratory to partner on various nuclear research and development efforts. Oak Ridge National Laboratory has signed a memorandum of understanding with the United Kingdom’s National Nuclear Laboratory to partner on various nuclear research and development efforts.](/sites/default/files/styles/list_page_thumbnail/public/NNL_MainImage.jpg?itok=8cSrtngA)
The United Kingdom’s National Nuclear Laboratory and the U.S. Department of Energy’s Oak Ridge National Laboratory have agreed to cooperate on a wide range of nuclear energy research and development efforts that leverage both organizations’ unique expertise and capabilities.
![The electromagnetic isotope separator system operates by vaporizing an element such as ruthenium into the gas phase, converting the molecules into an ion beam, and then channeling the beam through magnets to separate out the different isotopes. The electromagnetic isotope separator system operates by vaporizing an element such as ruthenium into the gas phase, converting the molecules into an ion beam, and then channeling the beam through magnets to separate out the different isotopes.](/sites/default/files/styles/list_page_thumbnail/public/6_1_17%20Ru_NF3_530uA%5B2%5D.jpg?itok=3OLnNZqa)
A tiny vial of gray powder produced at the Department of Energy’s Oak Ridge National Laboratory is the backbone of a new experiment to study the intense magnetic fields created in nuclear collisions.
![Radiochemical technicians David Denton and Karen Murphy use hot cell manipulators at Oak Ridge National Laboratory during the production of actinium-227. Radiochemical technicians David Denton and Karen Murphy use hot cell manipulators at Oak Ridge National Laboratory during the production of actinium-227.](/sites/default/files/styles/list_page_thumbnail/public/2016-P07827%5B1%5D.jpg?itok=yJbnFQLU)
The Department of Energy’s Oak Ridge National Laboratory is now producing actinium-227 (Ac-227) to meet projected demand for a highly effective cancer drug through a 10-year contract between the U.S. DOE Isotope Program and Bayer.
![Kevin Robb, a staff scientist at the Department of Energy’s Oak Ridge National Laboratory, is taking what he learned from developing the Liquid Salt Test Loop—a key tool in deploying molten salt technology applications Kevin Robb, a staff scientist at the Department of Energy’s Oak Ridge National Laboratory, is taking what he learned from developing the Liquid Salt Test Loop—a key tool in deploying molten salt technology applications](/sites/default/files/styles/list_page_thumbnail/public/news/images/2017-P03818_1.jpg?itok=qQLLL9dH)
Thanks in large part to developing and operating a facility for testing molten salt reactor (MSR) technologies, nuclear experts at the Energy Department’s Oak Ridge National Laboratory (ORNL) are now tackling the next generation of another type of clean energy—concentrating ...
![By producing 50 grams of plutonium-238, Oak Ridge National Laboratory researchers have demonstrated the nation’s ability to provide a valuable energy source for deep space missions. By producing 50 grams of plutonium-238, Oak Ridge National Laboratory researchers have demonstrated the nation’s ability to provide a valuable energy source for deep space missions.](/sites/default/files/styles/list_page_thumbnail/public/front_page_slide_assets/2015-P07524.jpg?itok=MEy22Na3)
With the production of 50 grams of plutonium-238, researchers at the Department of Energy’s Oak Ridge National Laboratory have restored a U.S. capability dormant for nearly 30 years and set the course to provide power for NASA and other missions.
![Pellet selector Pellet selector](/sites/default/files/styles/list_page_thumbnail/public/news/images/Fusion%20pellet%20art%202.jpg?itok=4KhWRcQt)
When it’s up and running, the ITER fusion reactor will be very big and very hot, with more than 800 cubic meters of hydrogen plasma reaching 170 million degrees centigrade. The systems that fuel and control it, on the other hand, will be small and very cold. Pellets of frozen gas will be shot int...