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Researchers studying secondary metabolites in the fungus Aspergillus flavus, pictured, found unique mixes of metabolites corresponding to genetically distinct populations. The finding suggests local environmental conditions play a key role in secondary metabolite production, influencing the discovery of drugs and other useful compounds. Credit: Tomás Allen Rush/ORNL, U.S. Dept. of Energy.

Scientists at ORNL and the University of Wisconsin–Madison have discovered that genetically distinct populations within the same species of fungi can produce unique mixes of secondary metabolites, which are organic compounds with applications in

Belinda Akpa applies her diverse expertise and high-performance computing to accelerate the drug discovery process and increase the chances of success when candidate molecules go to clinical trials. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Belinda Akpa is a chemical engineer with a talent for tackling big challenges and fostering inclusivity and diversity in the next generation of scientists.

Rich Giannone uses bioanalytical mass spectrometry to examine proteins, the primary driver in biological systems.

Rich Giannone uses bioanalytical mass spectrometry to examine proteins, the primary driver in biological systems.

ATOM logo

The Accelerating Therapeutics for Opportunities in Medicine , or ATOM, consortium today announced the U.S. Department of Energy’s Oak Ridge, Argonne and Brookhaven national laboratories are joining the consortium to further develop ATOM’s artificial intelligence, or AI-driven, drug discovery platform.

The Perseverance rover

On Feb. 18, the world will be watching as NASA’s Perseverance rover makes its final descent into Jezero Crater on the surface of Mars. Mars 2020 is the first NASA mission that uses plutonium-238 produced at the Department of Energy’s Oak Ridge National Laboratory.

ORNL’s Marcel Demarteau inspects experiments along Neutrino Alley at the Spallation Neutron Source, which makes neutrinos as a byproduct. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

Marcel Demarteau is director of the Physics Division at the Department of Energy’s Oak Ridge National Laboratory. For topics from nuclear structure to astrophysics, he shapes ORNL’s physics research agenda.

Fungi use signaling molecules called LCOs to communicate with each other and to regulate growth. Credit: Jessy Labbe/Oak Ridge National Laboratory, U.S. Dept. of Energy

Oak Ridge National Laboratory and collaborators have discovered that signaling molecules known to trigger symbiosis between plants and soil bacteria are also used by almost all fungi as chemical signals to communicate with each other.

coronavirus

NellOne Therapeutics has licensed a drug delivery system from the Department of Energy’s Oak Ridge National Laboratory that is designed to transport therapeutics directly to cells infected by SARS-CoV-2, the virus causing COVID-19.

ORNL assisted in investigating proteins called porins, one shown in red, which are found in the protective outer membrane of certain disease-causing bacteria and tether the membrane to the cell wall. Credit: Hyea (Sunny) Hwang/Georgia Tech and ORNL, U.S. Dept. of Energy

Scientists from Oak Ridge National Laboratory used high-performance computing to create protein models that helped reveal how the outer membrane is tethered to the cell membrane in certain bacteria.

Xunxiang Hu, a Eugene P. Wigner Fellow in ORNL’s Materials Science and Technology Division, designed this machine to produce large, crack-free pieces of yttrium hydride to be used as a moderator in the core of ORNL’s Transformational Challenge Reactor and other microreactors. Credit: Xunxiang Hu/ORNL, U.S. Dept. of Energy

About 60 years ago, scientists discovered that a certain rare earth metal-hydrogen mixture, yttrium, could be the ideal moderator to go inside small, gas-cooled nuclear reactors.