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An organic solvent and water separate and form nanoclusters on the hydrophobic and hydrophilic sections of plant material, driving the efficient deconstruction of biomass. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

Experiments led by researchers at ORNL have determined that several hepatitis C drugs can inhibit the SARS-CoV-2 main protease, a crucial protein enzyme that enables the novel coronavirus to reproduce.

The first neutron structure of the SARS-CoV-2 main protease enzyme revealed unexpected electrical charges in the amino acids cysteine (negative) and histidine (positive), providing key data about the virus’s replication. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

Fuel pellets sometimes degrade to a sandlike consistency and can disperse into the reactor core if a rod’s cladding bursts. ORNL researchers are studying how often this happens and what impact it has, in order to let reactors operate as long as possible without increasing risk.

A developing method to gauge the occurrence of a nuclear reactor anomaly has the potential to save millions of dollars.

Hector J. Santos-Villalobos, left, and Oscar A. Martinez

Two staff members at the Department of Energy’s Oak Ridge National Laboratory have received prestigious HENAAC and Luminary Awards from Great Minds in STEM, a nonprofit organization that focuses on promoting STEM careers in underserved 

Enzyme activity during organophosphate poisoning

Pick your poison. It can be deadly for good reasons such as protecting crops from harmful insects or fighting parasite infection as medicine — or for evil as a weapon for bioterrorism. Or, in extremely diluted amounts, it can be used to enhance beauty.

 Using the ASGarD mathematical framework, scientists can model and visualize the electric fields, shown as arrows, circling around magnetic fields that are colorized to represent field magnitude of a fusion plasma. Credit: David Green/ORNL

Combining expertise in physics, applied math and computing, Oak Ridge National Laboratory scientists are expanding the possibilities for simulating electromagnetic fields that underpin phenomena in materials design and telecommunications.

The protease protein is both shaped like a heart and functions as one, allowing the virus replicate and spread. Inhibiting the protease would block virus reproduction. Credit: Andrey Kovalevsky/ORNL, U.S. Dept. of Energy

A team of researchers has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease — the enzyme that enables the virus to reproduce.

ORNL researchers are leading virtual STEM outreach activities, such as an Internet of Things demonstration in which participants in ORCSGirls control an LED board remotely.

COVID-19 has upended nearly every aspect of our daily lives and forced us all to rethink how we can continue our work in a more physically isolated world.

ORNL scientists are currently using Proto-MPEX to perform necessary research and development that is needed to build MPEX. Credit: Genevieve Martin/Oak Ridge National Laboratory, U.S. Dept. of Energy

Temperatures hotter than the center of the sun. Magnetic fields hundreds of thousands of times stronger than the earth’s. Neutrons energetic enough to change the structure of a material entirely.

GIS – LandScan goes public

Oak Ridge National Laboratory’s high-resolution population distribution database, LandScan USA, became permanently available to researchers in time to aid the response to the novel coronavirus pandemic.