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The hCA II active site is flanked by hydrophilic (violet) and hydrophobic (green) binding pockets that can be used to design specific drugs targeting cancer-associated hCAs. Five clinical drugs are shown superimposed in the hCA II active site
New insights from neutron analysis of glaucoma drugs and their enzyme target may help scientists design drugs that more effectively target aggressive cancers. A team of researchers led by the Department of Energy’s Oak Ridge National Laboratory used neutro...
Germina Ilas (left) and Ian Gauld review spent fuel data entries in the SFCOMPO 2.0 database.
Oak Ridge National Laboratory provided significant contributions and coordination in the development of the Nuclear Energy Agency’s (NEA’s) recently released Spent Fuel Isotopic Composition (SFCOMPO) 2.0—the world’s largest open database for spent
In a model of a 1.6 liter engine cylinder, liquid fuel (shown in red and orange) is converted to fuel vapor under high temperatures during ignition. Image courtesy of Ronald Grover.

Most car owners in the United States do not think twice about passing over the diesel pump at the gas station. Instead, diesel fuel mostly powers our shipping trucks, boats, buses, and generators—and that is because diesel engines are about 10 percent more fuel-efficient than gaso...

A conceptual illustration of proton-proton fusion in which two protons fuse to form a deuteron. Image courtesy of William Detmold.

Nuclear physicists are using the nation’s most powerful supercomputer, Titan, at the Oak Ridge Leadership Computing Facility to study particle interactions important to energy production in the Sun and stars and to propel the search for new physics discoveries Direct calculatio...

ORNL and EPRI built an enclosed welding system in a hot cell of ORNL’s Radiochemical Engineering Development Center. C. Scott White (ORNL) performs operations with remotely controlled manipulators and cameras.

Scientists of the Department of Energy’s Light Water Reactor Sustainability Program (LWRS) and partners from the Electric Power Research Institute (EPRI) have conducted the first weld tests to repair highly irradiated materials at DOE’s Oak Ridge National Laboratory.

ORNL scientists estimated quantum computing energy usage from a detailed modeling technique. In a study, the team found that quantum computers could reduce energy usage by more than 20 orders of magnitude compared to conventional computers.
New research from Oak Ridge National Laboratory indicates that quantum computers will use dramatically less energy than current supercomputers, which could lead to cost savings for computing equipment manufacturers and data centers. “High-performance computers with thousands of pr...
Oak Ridge National Laboratory researcher Halil Tekinalp combines silanes and polylactic acid to create supertough renewable plastic.

A novel method developed at Oak Ridge National Laboratory creates supertough renewable plastic with improved manufacturability. Working with polylactic acid, a biobased plastic often used in packaging, textiles, biomedical implants and 3D printing, the research team added tiny amo...

An ORNL-led team conducts moisture durability simulations on construction materials, which will add real-world data to a new system developed to help builders and home designers make informed decisions. Credit: Rachel Brooks/Oak Ridge National Laboratory,

A new system being developed at Oak Ridge National Laboratory will help builders and home designers select the best construction materials for long-term moisture durability. “It has become challenging to make informed decisions because of modern building code requirements and new ...

Yarom Polsky

Yarom Polsky’s diverse background in private and public-sector research has given him a knack for recognizing opportunities to advance the state-of-the-art, and he parlays that knowledge into successful innovation as an engineer, group leader, and 

Brian Post is building the future of large-scale additive manufacturing at the Manufacturing Demonstration Facility at ORNL.

Brian Post came to the Department of Energy's Oak Ridge National Laboratory looking for a way to combine his interests in controls engineering and robotics, and he found it at the Manufacturing Demonstration Facility (MDF), where he and his colleagues are revolutionizing 3D-printi...