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An ORNL-led team studied the SARS-CoV-2 spike protein in the trimer state, shown here, to pinpoint structural transitions that could be disrupted to destabilize the protein and negate its harmful effects. Credit: Debsindhu Bhowmik/ORNL, U.S. Dept. of Energy

To explore the inner workings of severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, researchers from ORNL developed a novel technique.

The Energy Exascale Earth System Model project reliably simulates aspects of earth system variability and projects decadal changes that will critically impact the U.S. energy sector in the future. A new version of the model delivers twice the performance of its predecessor. Credit: E3SM, Dept. of Energy

A new version of the Energy Exascale Earth System Model, or E3SM, is two times faster than an earlier version released in 2018.

U.S. Secretary of Energy Granholm tours ORNL’s world-class science facilities

Energy Secretary Jennifer Granholm visited ORNL on Nov. 22 for a two-hour tour, meeting top scientists and engineers as they highlighted projects and world-leading capabilities that address some of the country’s most complex research and technical challenges. 

Benjamin Sulman, a scientist in ORNL’s Environmental Sciences Division, creates Earth system models that simulate how plants, microbes and soils interact and influence the cycling of carbon, water and nutrients in their environment. His work aims to helps researchers across disciplines better understand complex, rapidly changing ecosystems, including coastal wetlands and Arctic permafrost soils. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

As rising global temperatures alter ecosystems worldwide, the need to accurately simulate complex environmental processes under evolving conditions is more urgent than ever.

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.

Parans Paranthaman, a researcher in the Chemical Sciences Division at ORNL, coordinated research efforts to study the filter efficiency of the N95 material. His published results represent one of the first studies on polypropylene as it relates to COVID-19. Credit: ORNL/U.S. Dept. of Energy

When COVID-19 was declared a pandemic in March 2020, Oak Ridge National Laboratory’s Parans Paranthaman suddenly found himself working from home like millions of others.

Frontier supercomputer

A multi-institutional team, led by a group of investigators at Oak Ridge National Laboratory, has been studying various SARS-CoV-2 protein targets, including the virus’s main protease. The feat has earned the team a finalist nomination for the Association of Computing Machinery, or ACM, Gordon Bell Special Prize for High Performance Computing-Based COVID-19 Research.

coronavirus

NellOne Therapeutics has licensed a drug delivery system from the Department of Energy’s Oak Ridge National Laboratory that is designed to transport therapeutics directly to cells infected by SARS-CoV-2, the virus causing COVID-19.

U.S. Department of Energy Deputy Secretary Mark Menezes (right) tours the DemeTECH N95 filter material production area with Xin Sun, ORNL interim associate laboratory director (center) and Craig Blue, ORNL advanced manufacturing program manager. Credit: US Dept. of Energy

A collaboration between the ORNL and a Florida-based medical device manufacturer has led to the addition of 500 jobs in the Miami area to support the mass production of N95 respirator masks.

Emma Betters Thumbnail

Growing up in Florida, Emma Betters was fascinated by rockets and for good reason. Any time she wanted to see a space shuttle launch from NASA’s nearby Kennedy Space Center, all she had to do was sit on her front porch.