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ORNL scientists mutated amino acids in a receptor protein, shown in green, which diminished interaction with the SARS-CoV-2 virus spike protein, shown in red. Mutating the receptor protein hampered the virus’s ability to infect host cells. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

Artificial intelligence is becoming an increasingly valuable tool for ORNL researchers tackling the many mysteries of cancer. Credit: Getty Images.

A team of researchers from ORNL was recognized by the National Cancer Institute in March for their unique contributions in the fight against cancer.

One of the proteins identified through a new ORNL-developed approach could be key to communications between poplar trees and beneficial microbes that can help boost poplar trees’ growth, carbon storage and climate resilience. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

ORNL researchers have identified specific proteins and amino acids that could control bioenergy plants’ ability to identify beneficial microbes that can enhance plant growth and storage of carbon in soils.

The next generation of the Center for Bioenergy Innovation will pursue an accelerated feedstock-to-fuels approach for the efficient, economic production of sustainable jet fuel. Credit: ORNL, U.S. Dept. of Energy

The Center for Bioenergy Innovation has been renewed by the Department of Energy as one of four bioenergy research centers across the nation to advance robust, economical production of plant-based fuels and chemicals.

ORNL’s Adam Guss began adapting the SAGE gene editing tool to modify microbes in graduate school. Today, SAGE is rapidly accelerating the design of custom microbes for a variety of applications. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

A DNA editing tool adapted by Oak Ridge National Laboratory scientists makes engineering microbes for everything from bioenergy production to plastics recycling easier and faster.

Fungal geneticist Joanna Tannous is gaining a better understanding of the genetic processes behind fungal life to both combat plant disease and encourage beneficial processes like soil carbon storage. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Joanna Tannous has found the perfect organism to study to satisfy her deeply curious nature, her skills in biochemistry and genetics, and a drive to create solutions for a better world. The organism is a poorly understood life form that greatly influences its environment and is unique enough to deserve its own biological kingdom: fungi.

Computational systems biologists at ORNL worked with the U.S. Department of Veterans Affairs and other institutions to identify 139 locations across the human genome tied to risk factors for varicose veins, marking a first step in the development of new treatments. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

As part of a multi-institutional research project, scientists at ORNL leveraged their computational systems biology expertise and the largest, most diverse set of health data to date to explore the genetic basis of varicose veins.

State and Local Economic Development Award

A partnership of ORNL, the Tennessee Department of Economic and Community Development, the Community Reuse Organization of East Tennessee and TVA that aims to attract nuclear energy-related firms to Oak Ridge has been recognized with a state and local economic development award from the Federal Laboratory Consortium.

Hybrid poplar trees such as these shown in an ORNL greenhouse were engineered with the REVEILLE1 gene to delay dormancy and produce more biomass. The research was led by the Center for Bioenergy Innovation at ORNL with the Joint Genome Institute, Brookhaven National Laboratory, the HudsonAlpha Institute for Biotechnology, the University of Connecticut and other partners. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

A team of scientists led by ORNL discovered the gene in agave that governs when the plant goes dormant and used it to create poplar trees that nearly doubled in size, increasing biomass yield for biofuels production

Seven scientists at the Department of Energy’s Oak Ridge National Laboratory have been named Battelle Distinguished Inventors, in recognition of their obtaining 14 or more patents during their careers at the lab. Credit: ORNL, U.S. Dept. of Energy

Seven scientists at the Department of Energy’s Oak Ridge National Laboratory have been named Battelle Distinguished Inventors, in recognition of their obtaining 14 or more patents during their careers at the lab.