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Climate change often comes down to how it affects water, whether it’s for drinking, electricity generation, or how flooding affects people and infrastructure. To better understand these impacts, ORNL water resources engineer Sudershan Gangrade is integrating knowledge ranging from large-scale climate projections to local meteorology and hydrology and using high-performance computing to create a holistic view of the future.

Climate change often comes down to how it affects water, whether it’s for drinking, electricity generation, or how flooding affects people and infrastructure. To better understand these impacts, ORNL water resources engineer Sudershan Gangrade is integrating knowledge ranging from large-scale climate projections to local meteorology and hydrology and using high-performance computing to create a holistic view of the future.

ORNL scientists mutated amino acids in a receptor protein, shown in green, which diminished interaction with the SARS-CoV-2 virus spike protein, shown in red. Mutating the receptor protein hampered the virus’s ability to infect host cells. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

Oak Ridge National Laboratory led a team of scientists to design a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and future virus outbreaks. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

Initially, Celeritas will accelerate simulation of data from the Compact Muon Solenoid detector (shown schematically) at CERN’s Large Hadron Collider. Credit: Seth Johnson/ORNL, U.S. Dept. of Energy

Scientists at the Department of Energy’s Oak Ridge National Laboratory are leading a new project to ensure that the fastest supercomputers can keep up with big data from high energy physics research.

ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.

Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

A team of researchers used mathematics to predict which areas of the SARS-CoV-2 spike protein are most likely to mutate. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

Researchers from ORNL, the University of Tennessee at Chattanooga and Tuskegee University used mathematics to predict which areas of the SARS-CoV-2 spike protein are most likely to mutate.

Technology Innovation Program

Five technologies invented by scientists at the Department of Energy’s Oak Ridge National Laboratory have been selected for targeted investment through ORNL’s Technology Innovation Program.

ORNL’s RapidCure improves lithium-ion electrode production by producing electrodes faster, reducing the energy necessary for manufacturing and eliminating the need for a solvent recycling unit. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Researchers at the Department of Energy’s Oak Ridge National Laboratory and their technologies have received seven 2022 R&D 100 Awards, plus special recognition for a battery-related green technology product.

Bobby Sumpter. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL Corporate Fellow and Center for Nanophase Materials Sciences researcher Bobby Sumpter has been named fellow of two scientific professional societies: the Institute of Physics and the International Association of Advanced Materials.