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Seeing the difference Ac-225 could make to cancer patients made Raina Setzer want to come to ORNL to directly work with the isotope. Credit: Allison Peacock/ORNL, U.S. Dept. of Energy

Raina Setzer knows the work she does matters. That’s because she’s already seen it from the other side. Setzer, a radiochemical processing technician in Oak Ridge National Laboratory’s Isotope Processing and Manufacturing Division, joined the lab in June 2023.

Jason Gardner, Sandra Davern and Peter Thornton have been elected fellows of AAAS. Credit: Laddy Fields/ORNL, U.S. Dept. of Energy

Three scientists from the Department of Energy’s Oak Ridge National Laboratory have been elected fellows of the American Association for the Advancement of Science, or AAAS.

Researchers at Oak Ridge National Laboratory probed the chemistry of radium to gain key insights on advancing cancer treatments using radiation therapy. Credit: Adam Malin/ORNL, U.S. Dept. of Energy

Researchers at ORNL explored radium’s chemistry to advance cancer treatments using ionizing radiation.

Innovation Crossroads Cohort Six includes: Bianca Bailey, Agriwater; Rajan Kumar, Ateois Systems; Alex Stiles, Vitriform3D; Kim Tutin, Captis Aire; Anca Timofte, Holocene Climate; and Pete Willette, facil.ai. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory’s Innovation Crossroads program welcomes six new science and technology innovators from across the United States to the sixth cohort. 

In a study, ORNL researchers concluded that the most direct path to plastic upcycling is through designing polymers specifically for reuse, which would allow the material to be converted into high-value products. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory researchers determined that designing polymers specifically with upcycling in mind could reduce future plastic waste considerably and facilitate a circular economy where the material is used repeatedly.

ORNL researchers developed a novel process for manufacturing extreme heat resistant carbon-carbon composites at a faster rate and produced fins or strakes made of the materials for testing on a U.S. Navy rocket launching with NASA. Credit: ORNL, Sandia/U.S. Dept. of Energy

Oak Ridge National Laboratory researchers have developed a novel process to manufacture extreme heat resistant carbon-carbon composites. The performance of these materials will be tested in a U.S. Navy rocket that NASA will launch this fall.

Summer Widner, Stephanie Timbs, James Gaugler and James Avenell of ORNL are part of a team that processes thorium-228, a byproduct of actinium-227. As new uses for thorium are realized, particularly in medicine, the lab expects the demand for the radioisotope to grow.

As a medical isotope, thorium-228 has a lot of potential — and Oak Ridge National Laboratory produces a lot.

A 3D printed thermal protection shield, produced by ORNL researchers for NASA, is part of a cargo spacecraft bound for the International Space Station. The shield was printed at the Department of Energy’s Manufacturing Demonstration Facility at ORNL. Credit: ORNL, U.S. Dept. of Energy

A research team at Oak Ridge National Laboratory have 3D printed a thermal protection shield, or TPS, for a capsule that will launch with the Cygnus cargo spacecraft as part of the supply mission to the International Space Station.

Targeted alpha therapy can deliver radiation to specific cells, with minimal effect on surrounding, healthy cells. Credit: Michelle Lehman and Jaimee Janiga/ORNL, U.S. Dept. of Energy

A rare isotope in high demand for treating cancer is now more available to pharmaceutical companies developing and testing new drugs.

Sandra Davern performs cell based assays to evaluate cell death and DNA damage in response to radiation in order to gain a better understanding of how radioisotope nanoparticles affect the human body.

When Sandra Davern looks to the future, she sees individualized isotopes sent into the body with a specific target: cancer cells.