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ORNL scientists mutated amino acids in a receptor protein, shown in green, which diminished interaction with the SARS-CoV-2 virus spike protein, shown in red. Mutating the receptor protein hampered the virus’s ability to infect host cells. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

The yellow breasted chat is one of more than 200 bird species found on the Oak Ridge Reservation. Credit: Lee Smalley

The public is invited to six nature walks designed to highlight not only the rich flora and fauna diversity of the Oak Ridge Reservation, but also to demonstrate the work being done to sustainably manage and conserve this valuable resource.

Oak Ridge National Laboratory led a team of scientists to design a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and future virus outbreaks. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

One of the proteins identified through a new ORNL-developed approach could be key to communications between poplar trees and beneficial microbes that can help boost poplar trees’ growth, carbon storage and climate resilience. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

ORNL researchers have identified specific proteins and amino acids that could control bioenergy plants’ ability to identify beneficial microbes that can enhance plant growth and storage of carbon in soils.

The next generation of the Center for Bioenergy Innovation will pursue an accelerated feedstock-to-fuels approach for the efficient, economic production of sustainable jet fuel. Credit: ORNL, U.S. Dept. of Energy

The Center for Bioenergy Innovation has been renewed by the Department of Energy as one of four bioenergy research centers across the nation to advance robust, economical production of plant-based fuels and chemicals.

Samantha Peters co-designed and conducted experiments using ORNL’s high-performance mass spectrometry techniques to prove that bacteriophages deploy genetic code-switching to overwhelm and destroy host bacteria. Credit: Genevieve Martin, ORNL/U.S. Dept. of Energy

Scientists at ORNL have confirmed that bacteria-killing viruses called bacteriophages deploy a sneaky tactic when targeting their hosts: They use a standard genetic code when invading bacteria, then switch to an alternate code at later stages of

ORNL’s Adam Guss began adapting the SAGE gene editing tool to modify microbes in graduate school. Today, SAGE is rapidly accelerating the design of custom microbes for a variety of applications. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

A DNA editing tool adapted by Oak Ridge National Laboratory scientists makes engineering microbes for everything from bioenergy production to plastics recycling easier and faster.

Fungal geneticist Joanna Tannous is gaining a better understanding of the genetic processes behind fungal life to both combat plant disease and encourage beneficial processes like soil carbon storage. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Joanna Tannous has found the perfect organism to study to satisfy her deeply curious nature, her skills in biochemistry and genetics, and a drive to create solutions for a better world. The organism is a poorly understood life form that greatly influences its environment and is unique enough to deserve its own biological kingdom: fungi.

Oak Ridge National Laboratory’s Dave Weston works in a chamber at the DOE SPRUCE whole ecosystem experiment site in the peatlands of northern Minnesota. Credit: Kyle Pearson/ORNL, U.S. Dept. of Energy

A quest to understand how Sphagnum mosses facilitate the storage of vast amounts of carbon in peatlands led scientists to a surprising discovery: the plants have sex-based differences that appear to impact the carbon-storing process.

A new license to U2opia pairs two technologies developed in ORNL’s Cyber Resilience and Intelligence Division: Situ and Heartbeat. Credit: ORNL, U.S. Dept. of Energy

U2opia Technology, a consortium of technology and administrative executives with extensive experience in both industry and defense, has exclusively licensed two technologies from ORNL that offer a new method for advanced cybersecurity monitoring in real time.