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Neutron scattering experiments show electric charges, shown in red, blue and grey, in the SARS-CoV-2 main protease site where telaprevir binds to the structure. The experiments provide critical data for the design of small-molecule drugs to treat COVID-19. Credit: Jill Hemman and Michelle Lehman/ORNL, U.S. Dept. of Energy

Scientists have found new, unexpected behaviors when SARS-CoV-2 – the virus that causes COVID-19 – encounters drugs known as inhibitors, which bind to certain components of the virus and block its ability to reproduce.  

Researchers at ORNL and the University of Tennessee developed an automated workflow that combines chemical robotics and machine learning to speed the search for stable perovskites. Credit: Jaimee Janiga/ORNL, U.S. Dept of Energy

Researchers at the Department of Energy’s Oak Ridge National Laboratory and the University of Tennessee are automating the search for new materials to advance solar energy technologies.

Martin Wissink of ORNL’s Buildings and Transportation Science Division applies neutrons and other diagnostic tools at Oak Ridge National Laboratory in pursuit of cleaner, sustainable and more flexible transportation technologies. Credit: Genevieve Martin/ORNL, U.S. Dept of Energy

For a researcher who started out in mechanical engineering with a focus on engine combustion, Martin Wissink has learned a lot about neutrons on the job

Researchers at ORNL’s Center for Nanophase Materials Sciences and the University of Tennessee Health Science Center partnered to design a COVID-19 screening whistle for convenient home testing. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

Collaborators at Oak Ridge National Laboratory and the University of Tennessee Health Science Center are developing a breath-sampling whistle that could make COVID-19 screening easy to do at home.

Small, 3D-printed neutron collimators, designed by ORNL’s Jamie Molaison, yield reduced costs and manufacturing times and could enable new types of experiments. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

The ExOne Company, the global leader in industrial sand and metal 3D printers using binder jetting technology, announced it has reached a commercial license agreement with Oak Ridge National Laboratory to 3D print parts in aluminum-infiltrated boron carbide.

ORNL is designing a neutronic research engine to evaluate new materials and designs for advanced vehicles using the facilities at the Spallation Neutron Source at ORNL. Credit: Jill Hemman/ORNL, U.S. Dept of Energy, and  Southwest Research Institute.

In the quest for advanced vehicles with higher energy efficiency and ultra-low emissions, ORNL researchers are accelerating a research engine that gives scientists and engineers an unprecedented view inside the atomic-level workings of combustion engines in real time.

ORNL researchers have developed a new class of cobalt-free cathodes called NFA that are being investigated for making lithium-ion batteries for electric vehicles. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory researchers have developed a new family of cathodes with the potential to replace the costly cobalt-based cathodes typically found in today’s lithium-ion batteries that power electric vehicles and consumer electronics.

Six ORNL scientists have been elected as fellows to the American Association for the Advancement of Science, or AAAS. Credit: ORNL, U.S. Dept. of Energy

Six ORNL scientists have been elected as fellows to the American Association for the Advancement of Science, or AAAS.

The first neutron structure of the SARS-CoV-2 main protease enzyme revealed unexpected electrical charges in the amino acids cysteine (negative) and histidine (positive), providing key data about the virus’s replication. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

Shown here is an on-chip carbonized electrode microstructure from a scanning electron microscope. Credit: ORNL, U.S. Dept. of Energy

Scientists at Oak Ridge National Laboratory and the University of Tennessee designed and demonstrated a method to make carbon-based materials that can be used as electrodes compatible with a specific semiconductor circuitry.