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ORNL scientists mutated amino acids in a receptor protein, shown in green, which diminished interaction with the SARS-CoV-2 virus spike protein, shown in red. Mutating the receptor protein hampered the virus’s ability to infect host cells. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.

ORNL researchers proved that COVID-19 vaccines can be kept ultra-cool for an extended period in a retrofitted commercial storage container, providing a resource for safe delivery to remote locations. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory researchers have retrofitted a commercial refrigeration container designed to ensure COVID-19 vaccines remain at ultra-low temperatures during long transport and while locally stored.

ORNL’s green solvent enables environmentally friendly recycling of valuable Li-ion battery materials. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

Scientists at Oak Ridge National Laboratory have developed a solvent that results in a more environmentally friendly process to recover valuable materials from used lithium-ion batteries, supports a stable domestic supply chain for new batteries

A 3D printed turbine blade demonstrates the use of the new class of nickel-based superalloys that can withstand extreme heat environments without cracking or losing strength. Credit: ORNL/U.S. Dept. of Energy

Oak Ridge National Laboratory researchers have demonstrated that a new class of superalloys made of cobalt and nickel remains crack-free and defect-resistant in extreme heat, making them conducive for use in metal-based 3D printing applications.

self-healing elastomers
Researchers at Oak Ridge National Laboratory developed self-healing elastomers that demonstrated unprecedented adhesion strength and the ability to adhere to many surfaces, which could broaden their potential use
An X-ray CT image of a 3D-printed metal turbine blade was reconstructed using ORNL’s neural network and advanced algorithms. Credit: Amir Ziabari/ORNL, U.S. Dept. of Energy

Algorithms developed at Oak Ridge National Laboratory can greatly enhance X-ray computed tomography images of 3D-printed metal parts, resulting in more accurate, faster scans.

Cars and coronavirus

Oak Ridge National Laboratory researchers have developed a machine learning model that could help predict the impact pandemics such as COVID-19 have on fuel demand in the United States.

Drawing of thin-film cathode technology

Oak Ridge National Laboratory scientists seeking the source of charge loss in lithium-ion batteries demonstrated that coupling a thin-film cathode with a solid electrolyte is a rapid way to determine the root cause.

Batteries - The 3D connection

Oak Ridge National Laboratory researchers have developed a thin film, highly conductive solid-state electrolyte made of a polymer and ceramic-based composite for lithium metal batteries.