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ORNL scientists mutated amino acids in a receptor protein, shown in green, which diminished interaction with the SARS-CoV-2 virus spike protein, shown in red. Mutating the receptor protein hampered the virus’s ability to infect host cells. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

Researchers found that moderate levels of ash — sometimes found as spheres in biomass — do not significantly affect the mechanical properties of biocomposites made up of corn stover, switchgrass and PLA thermoplastic. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

The presence of minerals called ash in plants makes little difference to the fitness of new naturally derived compound materials designed for additive manufacturing, an Oak Ridge National Laboratory-led team found.

ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.

Scientists, from left, Parans Paranthaman, Tina Summers and Merlin Theodore at the DOE’s Carbon Fiber Technology Facility at ORNL are partnering with industry and university to develop antiviral materials for N95 masks. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory researchers collaborated with Iowa State University and RJ Lee Group to demonstrate a safe and effective antiviral coating for N95 masks. The coating destroys the COVID-19-causing coronavirus and could enable reuse of masks made from various fabrics.

ORNL researchers observed that atomic vibrations in a twisted crystal result in winding energetic waves that govern heat transport, which may help new materials better manage heat. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

A discovery by Oak Ridge National Laboratory researchers may aid the design of materials that better manage heat.

Researchers built optical tools called zero-mode waveguides, illustrated here, used to observe proteins that are implicated in human heart function. Credit: David S. White/University of Wisconsin-Madison

Researchers working with Oak Ridge National Laboratory developed a new method to observe how proteins, at the single-molecule level, bind with other molecules and more accurately pinpoint certain molecular behavior in complex

Researchers at ORNL’s Center for Nanophase Materials Sciences and the University of Tennessee Health Science Center partnered to design a COVID-19 screening whistle for convenient home testing. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

Collaborators at Oak Ridge National Laboratory and the University of Tennessee Health Science Center are developing a breath-sampling whistle that could make COVID-19 screening easy to do at home.

Fungi use signaling molecules called LCOs to communicate with each other and to regulate growth. Credit: Jessy Labbe/Oak Ridge National Laboratory, U.S. Dept. of Energy

Oak Ridge National Laboratory and collaborators have discovered that signaling molecules known to trigger symbiosis between plants and soil bacteria are also used by almost all fungi as chemical signals to communicate with each other.

ORNL assisted in investigating proteins called porins, one shown in red, which are found in the protective outer membrane of certain disease-causing bacteria and tether the membrane to the cell wall. Credit: Hyea (Sunny) Hwang/Georgia Tech and ORNL, U.S. Dept. of Energy

Scientists from Oak Ridge National Laboratory used high-performance computing to create protein models that helped reveal how the outer membrane is tethered to the cell membrane in certain bacteria.

Shown here is an on-chip carbonized electrode microstructure from a scanning electron microscope. Credit: ORNL, U.S. Dept. of Energy

Scientists at Oak Ridge National Laboratory and the University of Tennessee designed and demonstrated a method to make carbon-based materials that can be used as electrodes compatible with a specific semiconductor circuitry.