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Neutron experiments helped reveal the one-carbon enzymatic mechanism that synthesizes vital food sources for cancer cells that depend on vitamin B6, providing key insights into designing novel drugs to slow the spread of aggressive cancers. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

Neutrons seek to stop cancer from hijacking a metabolic highway

After a highly lauded research campaign that successfully redesigned a hepatitis C drug into one of the leading drug treatments for COVID-19, scientists at ORNL are now turning their drug design approach toward cancer. 

ORNL’s Fernanda Santos examines a soil sample at an NGEE Arctic field site in the Alaskan tundra in June 2022. Credit: Amy Breen, University of Alaska Fairbanks.

Scientists dig into wildfire predictions, long-term impacts

Wildfires are an ancient force shaping the environment, but they have grown in frequency, range and intensity in response to a changing climate. At ORNL, scientists are working on several fronts to better understand and predict these events and what they mean for the carbon cycle and biodiversity.

Upgrades to the particle accelerator enabling the record 1.7-megawatt beam power at the Spallation Neutron Source included adding 28 high-power radio-frequency klystrons (red tubes) to provide higher power for the accelerator. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

Spallation Neutron Source accelerator achieves world-record 1.7-megawatt power level to enable more scientific discoveries

The Spallation Neutron Source at the Department of Energy's Oak Ridge National Laboratory set a world record when its particle accelerator beam operating power reached 1.7 megawatts, substantially improving on the facility’s original design capability.

ORNL seismic researcher Chengping Chai placed seismic sensors on the ground at various distances from an ORNL nuclear reactor to learn whether they could detect its operating state. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Good vibrations: Seismic science draws clearer picture of clean energy

Like most scientists, Chengping Chai is not content with the surface of things: He wants to probe beyond to learn what’s really going on. But in his case, he is literally building a map of the world beneath, using seismic and acoustic data that reveal when and where the earth moves.

ORNL researchers, from left, Yang Liu, Xiaohan Yang and Torik Islam, collaborated on the development of a new capability to insert multiple genes simultaneously for fast, efficient transformation of plants into better bioenergy feedstocks. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

New approach ‘stacks’ genes for faster plant transformation

In a discovery aimed at accelerating the development of process-advantaged crops for jet biofuels, scientists at ORNL developed a capability to insert multiple genes into plants in a single step.

Radu Custelcean's sustainable chemistry for capturing carbon dioxide from air has been licensed to Holocene. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

Direct air capture technology licensed to Knoxville-based Holocene

An innovative and sustainable chemistry developed at ORNL for capturing carbon dioxide has been licensed to Holocene, a Knoxville-based startup focused on designing and building plants that remove carbon dioxide

Colleen Iversen is the new director of NGEE Arctic, leading a large cross-disciplinary team of scientists in pursuit of a better understanding of Arctic climate processes. Credit: ORNL, U.S. Dept. of Energy

Iversen named director of next-gen Arctic ecosystem project

Colleen Iversen, ecosystem ecologist, group leader and distinguished staff scientist, has been named director of the Next-Generation Ecosystem Experiments Arctic, or NGEE Arctic, a multi-institutional project studying permafrost thaw and other climate-related processes in Alaska.

The licensing and leadership team behind AMIGO. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL malware ‘vaccine’ generator licensed for Evasive.ai platform

A technology developed at ORNL and used by the U.S. Naval Information Warfare Systems Command, or NAVWAR, to test the capabilities of commercial security tools has been licensed to cybersecurity firm Penguin Mustache to create its Evasive.ai platform. The company was founded by the technology’s creator, former ORNL scientist Jared M. Smith, and his business partner, entrepreneur Brandon Bruce.

An illustration of the long-term evolution likely to occur as rising temperatures and subsequent thawing of frozen Arctic soils affects the northern Alaska tundra, as predicted by a high-performance model created by Oak Ridge National Laboratory. Credit: Adam Malin and Ethan Coon, ORNL/U.S. Dept. of Energy

Study finds sinking tundra surface unlikely to trigger runaway permafrost thaw

Oak Ridge National Laboratory scientists set out to address one of the biggest uncertainties about how carbon-rich permafrost will respond to gradual sinking of the land surface as temperatures rise.

A new license to U2opia pairs two technologies developed in ORNL’s Cyber Resilience and Intelligence Division: Situ and Heartbeat. Credit: ORNL, U.S. Dept. of Energy

Cybersecurity firm U2opia licenses ORNL technologies for advanced monitoring

U2opia Technology, a consortium of technology and administrative executives with extensive experience in both industry and defense, has exclusively licensed two technologies from ORNL that offer a new method for advanced cybersecurity monitoring in real time.