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ORNL scientists developed a method that improves the accuracy of the CRISPR Cas9 gene editing tool used to modify microbes for renewable fuels and chemicals production. This research draws on the lab’s expertise in quantum biology, artificial intelligence and synthetic biology. Credit: Philip Gray/ORNL, U.S. Dept. of Energy

Scientists at ORNL used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.

A beam of excited sodium-32 nuclei implants in the FRIB Decay Station initiator is used to detect decay signatures of isotopes. Credit: Gary Hollenhead, Toby King and Adam Malin/ORNL, U.S. Dept. of Energy

Timothy Gray of ORNL led a study that may have revealed an unexpected change in the shape of an atomic nucleus. The surprise finding could affect our understanding of what holds nuclei together, how protons and neutrons interact and how elements form.

ORNL’s Fernanda Santos examines a soil sample at an NGEE Arctic field site in the Alaskan tundra in June 2022. Credit: Amy Breen, University of Alaska Fairbanks.

Wildfires are an ancient force shaping the environment, but they have grown in frequency, range and intensity in response to a changing climate. At ORNL, scientists are working on several fronts to better understand and predict these events and what they mean for the carbon cycle and biodiversity.

ORNL researchers, from left, Yang Liu, Xiaohan Yang and Torik Islam, collaborated on the development of a new capability to insert multiple genes simultaneously for fast, efficient transformation of plants into better bioenergy feedstocks. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

In a discovery aimed at accelerating the development of process-advantaged crops for jet biofuels, scientists at ORNL developed a capability to insert multiple genes into plants in a single step.

ORNL researchers Michael Smith, Steven Pain and Kelly Chipps use JENSA, a unique gas jet system, for laboratory studies of nuclear reactions that also occur in neutron stars in binary systems. Credit: Steven Pain/ORNL, U.S. Dept. of Energy

Led by Kelly Chipps of ORNL, scientists working in the lab have produced a signature nuclear reaction that occurs on the surface of a neutron star gobbling mass from a companion star. Their achievement improves understanding of stellar processes generating diverse nuclear isotopes.

Colleen Iversen is the new director of NGEE Arctic, leading a large cross-disciplinary team of scientists in pursuit of a better understanding of Arctic climate processes. Credit: ORNL, U.S. Dept. of Energy

Colleen Iversen, ecosystem ecologist, group leader and distinguished staff scientist, has been named director of the Next-Generation Ecosystem Experiments Arctic, or NGEE Arctic, a multi-institutional project studying permafrost thaw and other climate-related processes in Alaska.

Kelly Chipps of Oak Ridge National Laboratory has been appointed to the Nuclear Sciences Advisory Committee, which advises the Department of Energy and National Science Foundation. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Kelly Chipps, a nuclear astrophysicist at ORNL, has been appointed to the Nuclear Science Advisory Committee, or NSAC. The committee provides official advice to DOE and the National Science Foundation, or NSF, about issues relating to the national program for basic nuclear science research.

Oak Ridge National Laboratory led a team of scientists to design a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and future virus outbreaks. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

Oak Ridge National Laboratory’s Dave Weston works in a chamber at the DOE SPRUCE whole ecosystem experiment site in the peatlands of northern Minnesota. Credit: Kyle Pearson/ORNL, U.S. Dept. of Energy

A quest to understand how Sphagnum mosses facilitate the storage of vast amounts of carbon in peatlands led scientists to a surprising discovery: the plants have sex-based differences that appear to impact the carbon-storing process.

Computational systems biologists at ORNL worked with the U.S. Department of Veterans Affairs and other institutions to identify 139 locations across the human genome tied to risk factors for varicose veins, marking a first step in the development of new treatments. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

As part of a multi-institutional research project, scientists at ORNL leveraged their computational systems biology expertise and the largest, most diverse set of health data to date to explore the genetic basis of varicose veins.