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Neutron experiments helped reveal the one-carbon enzymatic mechanism that synthesizes vital food sources for cancer cells that depend on vitamin B6, providing key insights into designing novel drugs to slow the spread of aggressive cancers. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

After a highly lauded research campaign that successfully redesigned a hepatitis C drug into one of the leading drug treatments for COVID-19, scientists at ORNL are now turning their drug design approach toward cancer. 

Upgrades to the particle accelerator enabling the record 1.7-megawatt beam power at the Spallation Neutron Source included adding 28 high-power radio-frequency klystrons (red tubes) to provide higher power for the accelerator. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

The Spallation Neutron Source at the Department of Energy's Oak Ridge National Laboratory set a world record when its particle accelerator beam operating power reached 1.7 megawatts, substantially improving on the facility’s original design capability.

Herwig shared the impacts of neutron science with Secretary of Energy Jennifer Granholm during a tour of SNS in November 2021. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Ken Herwig's scientific drive crystallized in his youth when he solved a tough algebra word problem in his head while tossing newspapers from his bicycle. He said the joy he felt in that moment as a teenager fueled his determination to conquer mathematical mysteries. And he did.

ORNL’s Yun Liu stands before one of the 10 laser comb-based beam diagnostics stations at the Spallation Neutron Source. The laser comb solves the longstanding problem of measuring changes in the beam across time. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

When opportunity meets talent, great things happen. The laser comb developed at ORNL serves as such an example.

ORNL seismic researcher Chengping Chai placed seismic sensors on the ground at various distances from an ORNL nuclear reactor to learn whether they could detect its operating state. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Like most scientists, Chengping Chai is not content with the surface of things: He wants to probe beyond to learn what’s really going on. But in his case, he is literally building a map of the world beneath, using seismic and acoustic data that reveal when and where the earth moves.

Radu Custelcean's sustainable chemistry for capturing carbon dioxide from air has been licensed to Holocene. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

An innovative and sustainable chemistry developed at ORNL for capturing carbon dioxide has been licensed to Holocene, a Knoxville-based startup focused on designing and building plants that remove carbon dioxide

ORNL researchers Michael Smith, Steven Pain and Kelly Chipps use JENSA, a unique gas jet system, for laboratory studies of nuclear reactions that also occur in neutron stars in binary systems. Credit: Steven Pain/ORNL, U.S. Dept. of Energy

Led by Kelly Chipps of ORNL, scientists working in the lab have produced a signature nuclear reaction that occurs on the surface of a neutron star gobbling mass from a companion star. Their achievement improves understanding of stellar processes generating diverse nuclear isotopes.

Kelly Chipps of Oak Ridge National Laboratory has been appointed to the Nuclear Sciences Advisory Committee, which advises the Department of Energy and National Science Foundation. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Kelly Chipps, a nuclear astrophysicist at ORNL, has been appointed to the Nuclear Science Advisory Committee, or NSAC. The committee provides official advice to DOE and the National Science Foundation, or NSF, about issues relating to the national program for basic nuclear science research.

Neutron scattering experiments at the Spallation Neutron Source revealed how the dynamics between copper and oxygen make a special type of enzyme excel at breaking down biomass. Insights could lead to lowering the cost of biofuel production. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

Nonfood, plant-based biofuels have potential as a green alternative to fossil fuels, but the enzymes required for production are too inefficient and costly to produce. However, new research is shining a light on enzymes from fungi that could make biofuels economically viable.

ORNL researchers used diamonds to compress materials to 1.2 million times ambient pressure and software to remove signal interference and extract data on pressure-induced atomic structures. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

For decades, scientists sought a way to apply the outstanding analytical capabilities of neutrons to materials under pressures approaching those surrounding the Earth’s core.