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Molecular dynamics simulations of the Fs-peptide revealed the presence of at least eight distinct intermediate stages during the process of protein folding. The image depicts a fully folded helix (1), various transitional forms (2–8), and one misfolded state (9). By studying these protein folding pathways, scientists hope to identify underlying factors that affect human health.

Using artificial neural networks designed to emulate the inner workings of the human brain, deep-learning algorithms deftly peruse and analyze large quantities of data. Applying this technique to science problems can help unearth historically elusive solutions.

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Working backwards has moved Josh Michener’s research far forward as he uses evolution and genetics to engineer microbes for better conversion of plants into biofuels and biochemicals. In his work for the BioEnergy Science Center at ORNL, for instance, “we’ve gotten good at engineering microbes th...