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Frances Pleasonton seals a vacuum chamber in 1951.

The old photos show her casually writing data in a logbook with stacks of lead bricks nearby, or sealing a vacuum chamber with a wrench. ORNL researcher Frances Pleasonton was instrumental in some of the earliest explorations of the properties of the neutron as the X-10 Site was finding its postwar footing as a research lab.

Vincente Guiseppe, co-spokesperson of the Majorana Collaboration and a research staff member at ORNL, in front of the Majorana Demonstrator shield on the 4850 Level of SURF. Credit: Nick Hubbard/Sanford Underground Research Facility

For nearly six years, the Majorana Demonstrator quietly listened to the universe. Nearly a mile underground at the Sanford Underground Research Facility, or SURF, in Lead, South Dakota, the experiment collected data that could answer one of the most perplexing questions in physics: Why is the universe filled with something instead of nothing?

Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

Larry Allard

Larry Allard, a distinguished research staff member at Oak Ridge National Laboratory, has been named a Fellow of the Microanalysis Society.

Scattering-type scanning near-field optical microscopy, a nondestructive technique in which the tip of the probe of a microscope scatters pulses of light to generate a picture of a sample, allowed the team to obtain insights into the composition of plant cell walls. Credit: Ali Passian/ORNL, U.S. Dept. of Energy

To optimize biomaterials for reliable, cost-effective paper production, building construction, and biofuel development, researchers often study the structure of plant cells using techniques such as freezing plant samples or placing them in a vacuum.

Oak Ridge National Laboratory’s Mitch Allmond works with the Facility for Rare Isotope Beams Decay Station initiator, which combined diverse detectors for FRIB’s first experiment. Credit: Robert Grzywacz/ORNL, U.S. Dept. of Energy

Two decades in the making, a new flagship facility for nuclear physics opened on May 2, and scientists from the Department of Energy’s Oak Ridge National Laboratory have a hand in 10 of its first 34 experiments.

Earth Day

Tackling the climate crisis and achieving an equitable clean energy future are among the biggest challenges of our time. 

An ORNL-led team studied the SARS-CoV-2 spike protein in the trimer state, shown here, to pinpoint structural transitions that could be disrupted to destabilize the protein and negate its harmful effects. Credit: Debsindhu Bhowmik/ORNL, U.S. Dept. of Energy

To explore the inner workings of severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, researchers from ORNL developed a novel technique.

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.

ORNL’s Sergei Kalinin and Rama Vasudevan (foreground) use scanning probe microscopy to study bulk ferroelectricity and surface electrochemistry -- and generate a lot of data. Credit: Jason Richards/ORNL, U.S. Dept. of Energy

At the Department of Energy’s Oak Ridge National Laboratory, scientists use artificial intelligence, or AI, to accelerate the discovery and development of materials for energy and information technologies.