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Media Contacts
![An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2021-06/frame1.png?h=d1cb525d&itok=51pwBWyP)
An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.
![ORNL has modeled the spike protein that binds the novel coronavirus to a human cell for better understanding of the dynamics of COVID-19. Credit: Stephan Irle/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2021-02/toc_notext_0.png?h=3474dc74&itok=zSrqLz3F)
To better understand the spread of SARS-CoV-2, the virus that causes COVID-19, Oak Ridge National Laboratory researchers have harnessed the power of supercomputers to accurately model the spike protein that binds the novel coronavirus to a human cell receptor.
![Frontier supercomputer](/sites/default/files/styles/list_page_thumbnail/public/2023-01/frontier_0.jpg?h=a1e1a043&itok=J3IM_Xeh)
A multi-institutional team, led by a group of investigators at Oak Ridge National Laboratory, has been studying various SARS-CoV-2 protein targets, including the virus’s main protease. The feat has earned the team a finalist nomination for the Association of Computing Machinery, or ACM, Gordon Bell Special Prize for High Performance Computing-Based COVID-19 Research.
![ORNL assisted in investigating proteins called porins, one shown in red, which are found in the protective outer membrane of certain disease-causing bacteria and tether the membrane to the cell wall. Credit: Hyea (Sunny) Hwang/Georgia Tech and ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-11/Biology-gram-negative_0.jpg?h=ced0ee1c&itok=mTOudglI)
Scientists from Oak Ridge National Laboratory used high-performance computing to create protein models that helped reveal how the outer membrane is tethered to the cell membrane in certain bacteria.
![A selfie from the Curiosity rover as it explores the surface of Mars. Like many spacecraft, Curiosity uses a radioisotope power system to help fuel its mission. Credit: NASA/JPL-Caltech/MSSS](/sites/default/files/styles/list_page_thumbnail/public/2020-09/Curiousity_1.jpg?h=86a9dded&itok=Jo0vD321)
Radioactive isotopes power some of NASA’s best-known spacecraft. But predicting how radiation emitted from these isotopes might affect nearby materials is tricky
![Fuel pellets sometimes degrade to a sandlike consistency and can disperse into the reactor core if a rod’s cladding bursts. ORNL researchers are studying how often this happens and what impact it has, in order to let reactors operate as long as possible without increasing risk.](/sites/default/files/styles/list_page_thumbnail/public/2020-08/X2001338_FuelFragmentation_GraphicUpdate_Bumpus_jnj-02_0.jpg?h=049a2720&itok=mzNfF2cS)
A developing method to gauge the occurrence of a nuclear reactor anomaly has the potential to save millions of dollars.
![Simulation of short polymer chains](/sites/default/files/styles/list_page_thumbnail/public/2020-08/Screen%20Shot%202020-07-27%20at%202.46.08%20PM_0.png?h=fc4031ca&itok=DVcIeNaW)
Oak Ridge National Laboratory scientists have discovered a cost-effective way to significantly improve the mechanical performance of common polymer nanocomposite materials.
![Quantum Science Center](/sites/default/files/styles/list_page_thumbnail/public/2020-08/QSC1119x478_0.jpg?h=bc8e7609&itok=aajhUtmU)
The Department of Energy has selected Oak Ridge National Laboratory to lead a collaboration charged with developing quantum technologies that will usher in a new era of innovation.
![VERA’s tools allow a virtual window inside the reactor core, down to a molecular level.](/sites/default/files/styles/list_page_thumbnail/public/2020-08/Godfrey_2d_pin_power.png?h=507248e9&itok=SIcNrXUE)
As CASL ends and transitions to VERA Users Group, ORNL looks at the history of the program and its impact on the nuclear industry.
![Solid radium sulfate sits in the bottom of a flask during the recovery process. Credit: Oak Ridge National Laboratory, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-06/Ac227%202.jpg?h=479d286c&itok=AiNceGva)
Oak Ridge National Laboratory researchers have discovered a better way to separate actinium-227, a rare isotope essential for an FDA-approved cancer treatment.