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A new method uses E. coli to generate DNA with methylation patterns that target microbes recognize and accept as their own, facilitating customization of microbes for biofuels production.

Scientists at the US Department of Energy’s Oak Ridge National Laboratory have demonstrated a method to insert genes into a variety of microorganisms that previously would not accept foreign DNA, with the goal of creating custom microbes to break down plants for bioenergy.

Stephanie Galanie

Early career scientist Stephanie Galanie has applied her expertise in synthetic biology to a number of challenges in academia and private industry. She’s now bringing her skills in high-throughput bio- and analytical chemistry to accelerate research on feedstock crops as a Liane B. Russell Fellow at Oak Ridge National Laboratory.

ORNL staff members (from left) Ashley Shields, Michael Galloway, Ketan Maheshwari and Andrew Miskowiec are collaborating on a project focused on predicting and analyzing crystal structures of new uranium oxide phases. Credit: Jason Richards/ORNL

Scientists at the Department of Energy’s Oak Ridge National Laboratory are working to understand both the complex nature of uranium and the various oxide forms it can take during processing steps that might occur throughout the nuclear fuel cycle.

Molecular dynamics simulations of the Fs-peptide revealed the presence of at least eight distinct intermediate stages during the process of protein folding. The image depicts a fully folded helix (1), various transitional forms (2–8), and one misfolded state (9). By studying these protein folding pathways, scientists hope to identify underlying factors that affect human health.

Using artificial neural networks designed to emulate the inner workings of the human brain, deep-learning algorithms deftly peruse and analyze large quantities of data. Applying this technique to science problems can help unearth historically elusive solutions.

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While studying the genes in poplar trees that control callus formation, scientists at Oak Ridge National Laboratory have uncovered genetic networks at the root of tumor formation in several human cancers.

Joseph Lukens, Raphael Pooser, and Nick Peters (from left) of ORNL’s Quantum Information Science Group developed and tested a new interferometer made from highly nonlinear fiber in pursuit of improved sensitivity at the quantum scale. Credit: Carlos Jones

By analyzing a pattern formed by the intersection of two beams of light, researchers can capture elusive details regarding the behavior of mysterious phenomena such as gravitational waves. Creating and precisely measuring these interference patterns would not be possible without instruments called interferometers.