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Media Contacts
![The researchers used the new model to accurately identify clusters of gene mutations (spheres), which helped them study the emergence of various genetic diseases. Image credit: Ivaylo Ivanov, Georgia State University.](/sites/default/files/styles/list_page_thumbnail/public/2019-05/med-res-image6_3mb-1.png?h=bf86d530&itok=wTUjuyV_)
Environmental conditions, lifestyle choices, chemical exposure, and foodborne and airborne pathogens are among the external factors that can cause disease. In contrast, internal genetic factors can be responsible for the onset and progression of diseases ranging from degenerative neurological disorders to some cancers.
![The illustrations show how the correlation between lattice distortion and proton binding energy in a material affects proton conduction in different environments. Mitigating this interaction could help researchers improve the ionic conductivity of solid materials.](/sites/default/files/styles/list_page_thumbnail/public/2019-05/Figure_Rosenthal_5-1-19_0.png?h=73c01546&itok=-tjVhDfm)
Ionic conduction involves the movement of ions from one location to another inside a material. The ions travel through point defects, which are irregularities in the otherwise consistent arrangement of atoms known as the crystal lattice. This sometimes sluggish process can limit the performance and efficiency of fuel cells, batteries, and other energy storage technologies.
![ORNL staff members (from left) Ashley Shields, Michael Galloway, Ketan Maheshwari and Andrew Miskowiec are collaborating on a project focused on predicting and analyzing crystal structures of new uranium oxide phases. Credit: Jason Richards/ORNL](/sites/default/files/styles/list_page_thumbnail/public/2019-03/teamphotoforhighlight_0.jpg?h=a00326b7&itok=O4yDtVj6)
Scientists at the Department of Energy’s Oak Ridge National Laboratory are working to understand both the complex nature of uranium and the various oxide forms it can take during processing steps that might occur throughout the nuclear fuel cycle.
![Molecular dynamics simulations of the Fs-peptide revealed the presence of at least eight distinct intermediate stages during the process of protein folding. The image depicts a fully folded helix (1), various transitional forms (2–8), and one misfolded state (9). By studying these protein folding pathways, scientists hope to identify underlying factors that affect human health.](/sites/default/files/styles/list_page_thumbnail/public/2019-03/Slide1_0.png?h=c855054e&itok=aNbgxXsc)
Using artificial neural networks designed to emulate the inner workings of the human brain, deep-learning algorithms deftly peruse and analyze large quantities of data. Applying this technique to science problems can help unearth historically elusive solutions.
![Coexpression_hi-res_image[1].jpg Coexpression_hi-res_image[1].jpg](/sites/default/files/styles/list_page_thumbnail/public/Coexpression_hi-res_image%5B1%5D_0.jpg?itok=OnLe-krT)
While studying the genes in poplar trees that control callus formation, scientists at Oak Ridge National Laboratory have uncovered genetic networks at the root of tumor formation in several human cancers.
![ORNL’s Manjunath Gorentla Venkata helped develop a new approach to analyze thousands of genetic samples by connecting powerful computing resources. ORNL’s Manjunath Gorentla Venkata helped develop a new approach to analyze thousands of genetic samples by connecting powerful computing resources.](/sites/default/files/styles/list_page_thumbnail/public/news/images/2016-P05087.jpg?itok=mSLI1AgK)
ORNL helps develop hybrid computational strategy for efficient sequencing of massive genome datasets
Computing experts at the Department of Energy’s Oak Ridge National Laboratory collaborated with a team of university researchers and software companies to develop a novel hybrid computational strategy to efficiently discover genetic variants