Case closed: Neutrons settle 40-year debate on enzyme for drug design
Scientists at ORNL used neutrons to end a decades-long debate about an enzyme cancer uses.
A team led by scientists at ORNL identified and demonstrated a method to process a plant-based material called nanocellulose that reduced energy needs by a whopping 21%, using simulations on the lab’s supercomputers and follow-on analysis.
Debjani Singh, a senior scientist at ORNL, leads the HydroSource project, which enhances hydropower research by making water data more accessible and useful. With a background in water resources, data science, and earth science, Singh applies innovative tools like AI to advance research. Her career, shaped by her early exposure to science in India, focuses on bridging research with practical applications.
Brian Sanders is focused on impactful, multidisciplinary science at Oak Ridge National Laboratory, developing solutions for everything from improved imaging of plant-microbe interactions that influence ecosystem health to advancing new treatments for cancer and viral infections.
To better predict long-term flooding risk, scientists at the Department of Energy’s Oak Ridge National Laboratory developed a 3D modeling framework that captures the complex dynamics of water as it flows across the landscape. The framework seeks to provide valuable insights into which communities are most vulnerable as the climate changes, and was developed for a project that’s assessing climate risk and mitigation pathways for an urban area along the Southeast Texas coast.
Oak Ridge National Laboratory scientists have developed a method leveraging artificial intelligence to accelerate the identification of environmentally friendly solvents for industrial carbon capture, biomass processing, rechargeable batteries and other applications.
When Oak Ridge National Laboratory's science mission takes staff off-campus, the lab’s safety principles follow. That’s true even in the high mountain passes of Washington and Oregon, where ORNL scientists are tracking a tree species — and where wildfires have become more frequent and widespread.
John Lagergren, a staff scientist in Oak Ridge National Laboratory’s Plant Systems Biology group, is using his expertise in applied math and machine learning to develop neural networks to quickly analyze the vast amounts of data on plant traits amassed at ORNL’s Advanced Plant Phenotyping Laboratory.
The BIO-SANS instrument, located at Oak Ridge National Laboratory’s High Flux Isotope Reactor, is the latest neutron scattering instrument to be retrofitted with state-of-the-art robotics and custom software. The sophisticated upgrade quadruples the number of samples the instrument can measure automatically and significantly reduces the need for human assistance.
Plans to unite the capabilities of two cutting-edge technological facilities funded by the Department of Energy’s Office of Science promise to usher in a new era of dynamic structural biology. Through DOE’s Integrated Research Infrastructure, or IRI, initiative, the facilities will complement each other’s technologies in the pursuit of science despite being nearly 2,500 miles apart.