In this work, loss analysis and mapping of a segmented two-level inverter based on SiC MOSFETs are presented to identify the challenges in integration of power electronics and electric machines for EV applications. The paper starts with description of the segmented inverter topology, power device sizing and the EV traction system that is chosen as the study case. The analytical switching, conduction and dead-time loss analysis for the SiC MOSFETs in the segmented two-level inverter topology are presented under any given operating condition. The analysis is followed by loss mapping of the motor, inverter and overall EV traction system. The loss and efficiency maps of the inverter and the motor shows that each component has different thermal loading trends under given torque-speed characteristics.