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Modern weapons technologies often keep members of the military out of harm's way by allowing them to perform missions from a distance. Researchers at the Department of Energy’s Oak Ridge National Laboratory are helping the military play defense from a distance, as well.
If you’ve ever been stuck in traffic on a hot, sunny afternoon, you might have noticed the rippling effect caused by the release of even hotter exhaust fumes. If so, you’ve watched opportunity drift away.
Award-winning geneticist Liane Russell has written a history of Oak Ridge National Laboratory's fabled Mouse House, where she and husband William led a research program that charted significant advances in the field of mammalian genetics and mutagenesis.
Bio-SANS, the Biological Small-Angle Neutron Scattering Instrument at HFIR recently had a detector upgrade that will provide significantly improved performance that is more in line with the instrument’s capability.
We now know that many serious diseases have genetic links that a geneticist can find by reading an individual’s genome─the DNA double helix where our organism’s hereditary information is encoded. Researchers know too that a particular protein protects our DNA, which is vulnerable to entanglement when its information is read and to attack from enzymes that damage the strands, making the code indecipherable.
Researchers at the Bio-SANS instrument at the High Flux Isotope Reactor (HFIR) used small-angle neutron scattering (SANS) to get a first insight into the conformation of single polyelectrolyte chains in large pieces of the synthetic complex. The research pursues applications for replacement of intervertebral discs in the spine and of knee cartilage.
Researchers have long thought that formation of insoluble fibrous “strings” of self-assembling proteins might be involved in the progression of a number of diseases, including neurodegenerative disorders such as Alzheimer’s and Parkinson’s. However, recent evidence suggests that aggregates that develop at an earlier stage than fibril formation, and accumulate in human organs, may be the primary toxic agents.
The generation of bioethanol from lignocellulosic biomass holds great promise for renewable and clean energy production. However, this type of biomass is a complex, composite biological material that shows significant recalcitrance to enzymatic breakdown into sugars that can be used for fermentation, currently making it cost-ineffective as an ethanol source. The present research provides insight into the consequences of dilute acid pretreatment of biomass through direct observation by small-angle neutron scattering (SANS) of structural features in cellulose extracted from switchgrass over length scales from 10 to 6000 Å.