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Our plan for this section is to outline the best practices for sample preparation, data acquisition, reduction and analysis for Bio-SANS experiments in an effort to lower the technical barrier for new users of small angle neutron scattering. As an example, the following video from the Journal of Visualized Experiments includes information on experimental planning, deuteration, and the use of SANS with contrast matching for a study of the structure of an intramembrane aspartyl protease.