The Center for Molecular Biophysics (CMB) at Oak Ridge National Laboratory (ORNL) has been advancing molecular science since 2006, with support from ORNL and the University of Tennessee. The center conducts research at the intersection of biology, chemistry, physics, computation, and neutron sciences, using high-performance computer simulations and biophysical experiments to study the structure and function of biologically relevant molecular systems.
The Center for Structural Molecular Biology at ORNL is dedicated to developing instrumentation and methods for determining the 3-dimensional structures of proteins, nucleic acids (DNA/RNA) and their higher order complexes. The tools of the CSMB will help understand how these macromolecular systems are formed and how they interact with other systems in living cells. The focus of the CSMB is to bridge the information gap between cellular function and the molecular mechanisms that drive it.