Engineered Microorganisms for the Production of Intermediates and Final Products

Conversion of plant material into value add products will be critical for replacing fossil fuel-derived molecules in the chemical industry to enable a renewable bioeconomy, and microorganisms provide a potential biocatalyst that can perform these conversions. However, natural microbes typically do not possess pathways optimized for high titer, rate, and yield production of desired molecules. Here, we provide a genetic modification that can increase yield of certain chemicals in an engineered microorganism when converting plant sugars into chemicals.