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Mechanism-Based Biological Inference via Multiplex Networks, AI Agents and Cross-Species Translation
This invention provides a platform that uses AI agents and biological networks to uncover and interpret disease-relevant biological mechanisms.

By engineering the Serine Integrase Assisted Genome Engineering (SAGE) genetic toolkit in an industrial strain of Aspergillus niger, we have established its proof of principle for applicability in Eukaryotes.

This manufacturing method uses multifunctional materials distributed volumetrically to generate a stiffness-based architecture, where continuous surfaces can be created from flat, rapidly produced geometries.

Through utilizing a two function splice we can increase the splice strength for opposing tows.
Contact:
To learn more about this technology, email partnerships@ornl.gov or call 865-574-1051.

The lack of real-time insights into how materials evolve during laser powder bed fusion has limited the adoption by inhibiting part qualification. The developed approach provides key data needed to fabricate born qualified parts.

We present a comprehensive muti-technique approach for systematic investigation of enzymes generated by wastewater Comamonas species with hitherto unknown functionality to wards the depolymerization of plastics into bioaccessible products for bacterial metabolism.

The use of biomass fiber reinforcement for polymer composite applications, like those in buildings or automotive, has expanded rapidly due to the low cost, high stiffness, and inherent renewability of these materials. Biomass are commonly disposed of as waste.

This invention introduces a continuous composite forming process that produces large parts with variable cross-sections and shapes, exceeding the size of the forming machine itself.