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ORNL scientists identified four amino acids key to signaling pathways in the PAN protein domain. Mutating any of those disrupted the signal that tells cancer cells to multiply. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

A Protein Domain Modulating Host-Cell Invasion

An ORNL team has developed a method for screening for an immunoregulatory protein, which includes assessing the sequence of a candidate protein to determine if it is an immunoregulatory protein when at least one plasminogen-apple-nematode (PAN) domain with a consensus sequence