Limited availability of 229Th for clinical applications of 213Bi necessitates investigation of alternative production routes. In reactor production, 229Th is produced from neutron transmutation of 226Ra, 228Ra, 227Ac and 228Th. We evaluate irradiations of 226Ra, 228Ra, and 227Ac targets at the ORNL High Flux Isotope Reactor. Yields of 229Th at 25 days are 2.0 ± 0.2 mCi/g, 32.3 ± 1.3 mCi/g, and 7.0 ± 0.3 mCi/g, for 226Ra, 227Ac, and 228Ra respectively. Intermediate radionuclide yields and cross-sections are also studied.