Summit supercomputer draws molecular blueprint for repairing damaged DNA
Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair. Decoding NER’s sophisticated sequence of events and the role of PInC in the pathway could provide key insights into developing novel treatments and preventing conditions that lead to premature aging and certain types of cancer.
Ryan Culler is the program manager at Oak Ridge National Laboratory, where he oversees the production of actinium-225, a promising treatment for cancer. Driven by a personal connection to cancer through his late brother, Culler is dedicated to advancing medical isotopes to help improve cancer care.
Scientists conducted a groundbreaking study on the genetic data of over half a million U.S. veterans, using tools from the Oak Ridge National Laboratory to analyze 2,068 traits from the Million Veteran Program.
Researchers used the world’s fastest supercomputer, Frontier, to train an AI model that designs proteins, with applications in fields like vaccines, cancer treatments, and environmental bioremediation. The study earned a finalist nomination for the Gordon Bell Prize, recognizing innovation in high-performance computing for science.
A team of researchers used the Frontier supercomputer and a new methodology for conducting a genome-wide association study to earn a finalist nomination for the Association for Computing Machinery’s 2024 Gordon Bell Prize for outstanding
Biochemist David Baker — just announced as a recipient of the Nobel Prize for Chemistry — turned to the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory for information he couldn’t get anywhere else. HFIR is the strongest reactor-based neutron source in the United States.
Scientists at ORNL used neutrons to end a decades-long debate about an enzyme cancer uses.
After retiring from Y-12, Scott Abston joined the Isotope Science and Engineering Directorate to support isotope production and work with his former manager. He now leads a team maintaining critical equipment for medical and space applications. Abston finds fulfillment in mentoring his team and is pleased with his decision to continue working.
Jeremiah Sewell leads a team at ORNL, working on xenon-129 production for lung imaging. Reflecting on his career, Sewell views each opportunity as a "door" he steps through, leveraging over 25 years of experience in nuclear power and centrifuge operations to advance the facility’s mission.
Brian Sanders is focused on impactful, multidisciplinary science at Oak Ridge National Laboratory, developing solutions for everything from improved imaging of plant-microbe interactions that influence ecosystem health to advancing new treatments for cancer and viral infections.