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ORNL researcher Priya Ranjan standing outside in front of brick pillars

From decoding plant genomes to modeling microbial behavior, computational biologist Priya Ranjan builds computational tools that turn extensive biological datasets into real-world insights. These tools transform the way scientists ask and answer complex biological questions that advance biotechnology breakthroughs and support cultivation of better crops for energy and food security. 

A 3D printing nozzle wrapped in insulation extrudes black composite material into a small square mold on a green and white flat surface in a lab setting. Inset shows a close-up of a pressure gauge connected to brass valves and tubing.

Scientists at ORNL have developed a vacuum-assisted extrusion method that reduces internal porosity by up to 75% in large-scale 3D-printed polymer parts. This new technique addresses the critical issue of porosity in large-scale prints but also paves the way for stronger composites. 

ORNL researcher Jesse Labbe is working with plants in a greenhouse. He is framed on all sides with bright green leaves

Jesse Labbé aims to leverage biology, computation and engineering to address societal challenges related to energy, national security and health, while enhancing U.S. competitiveness. Labbé emphasizes the importance of translating groundbreaking research into practical applications that have real-world impact.

A 3D rendering of a large, white protein complex bound to a purple strand of guide RNA, which is aligned with a blue double-helix DNA strand. The background is a soft gray with scattered, blurred molecular shapes.

Scientists at Oak Ridge National Laboratory and the University of Colorado Boulder used a gene-silencing tool and a large library of molecular guides to understand how photosynthetic bacteria adapt to light and temperature changes. They found that even partial suppression of certain genes yielded big benefits in modifying the stress response of wild microbes. 

Scientist standing beside mass spectrometry equipment in a laboratory, with instrumentation panels and analysis tools visible in the background

Robert “Bob” Hettich, an ORNL Corporate Fellow, is a pioneer in using mass spectrometry to uncover how microbes interact within complex environments and influence larger systems like plants and humans. A founder of the field of metaproteomics, he leads research that supports bioenergy, environmental resilience and health through advanced protein analysis.

Researcher is sitting in bio lab surrounded with plants

Dave Weston studies how microorganisms influence plant health and stress tolerance, using the Advanced Plant Phenotyping Laboratory to accelerate research on plant-microbe interactions and develop resilient crops for advanced fuels, chemicals and 

Hugh O'Neil, director or ORNL's Center for Structural Molecular Biology is sitting in the lab on a stool, hand on desk with glasses on. There are lab related items blurred in the foreground.

Hugh O’Neill’s lifelong fascination with the complexities of the natural world drives his research at ORNL, where he’s using powerful neutron beams to dive deep into the microscopic realm of biological materials and unlock secrets for better production of domestic biofuels and bioproducts.

A male researcher is standing next to a poster board displayed on an easel to the right. The researcher is dressed in professional attire, and the poster board is positioned beside him, showing research or visual information.

Ryan Culler is the program manager at Oak Ridge National Laboratory, where he oversees the production of actinium-225, a promising treatment for cancer. Driven by a personal connection to cancer through his late brother, Culler is dedicated to advancing medical isotopes to help improve cancer care. 

ORNL researcher Phong Le poses for a photo outside on a walkway bridge over the pond. The photo is framed with brown and green plants

Phong Le is a computational hydrologist at ORNL who is putting his skills in hydrology, numerical modeling, machine learning and high-performance computing to work quantifying water-related risks for humans and the environment. 

ORNL researcher is sitting on a desk with his hands crossed, three screens behind him depicting work in satellites and space. Pictures on the left and right are orange in color while the middle photo is blue and reflects an image from space

From during his early years at NASA to his current role a researcher and group leader, Peter Fuhr has pushed the boundaries of optical and sensor technology. Fuhr’s path is marked by wacky creativity that can’t confine itself to challenges in a single field. No idea is too far out to try out — and so many of them work that Fuhr has a host of inventions and start-ups under his belt.