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ORNL researcher Priya Ranjan standing outside in front of brick pillars

From decoding plant genomes to modeling microbial behavior, computational biologist Priya Ranjan builds computational tools that turn extensive biological datasets into real-world insights. These tools transform the way scientists ask and answer complex biological questions that advance biotechnology breakthroughs and support cultivation of better crops for energy and food security. 

Illustration of melting point of lithium chloride, which is shown with green and blue structures in two rows.

Scientists have developed a new machine learning approach that accurately predicted critical and difficult-to-compute properties of molten salts, materials with diverse nuclear energy applications. 

ORNL researcher Jesse Labbe is working with plants in a greenhouse. He is framed on all sides with bright green leaves

Jesse Labbé aims to leverage biology, computation and engineering to address societal challenges related to energy, national security and health, while enhancing U.S. competitiveness. Labbé emphasizes the importance of translating groundbreaking research into practical applications that have real-world impact.

A 3D rendering of a large, white protein complex bound to a purple strand of guide RNA, which is aligned with a blue double-helix DNA strand. The background is a soft gray with scattered, blurred molecular shapes.

Scientists at Oak Ridge National Laboratory and the University of Colorado Boulder used a gene-silencing tool and a large library of molecular guides to understand how photosynthetic bacteria adapt to light and temperature changes. They found that even partial suppression of certain genes yielded big benefits in modifying the stress response of wild microbes. 

Scientist standing beside mass spectrometry equipment in a laboratory, with instrumentation panels and analysis tools visible in the background

Robert “Bob” Hettich, an ORNL Corporate Fellow, is a pioneer in using mass spectrometry to uncover how microbes interact within complex environments and influence larger systems like plants and humans. A founder of the field of metaproteomics, he leads research that supports bioenergy, environmental resilience and health through advanced protein analysis.

Researcher is sitting in bio lab surrounded with plants

Dave Weston studies how microorganisms influence plant health and stress tolerance, using the Advanced Plant Phenotyping Laboratory to accelerate research on plant-microbe interactions and develop resilient crops for advanced fuels, chemicals and 

Hugh O'Neil, director or ORNL's Center for Structural Molecular Biology is sitting in the lab on a stool, hand on desk with glasses on. There are lab related items blurred in the foreground.

Hugh O’Neill’s lifelong fascination with the complexities of the natural world drives his research at ORNL, where he’s using powerful neutron beams to dive deep into the microscopic realm of biological materials and unlock secrets for better production of domestic biofuels and bioproducts.

ORNL researcher Phong Le poses for a photo outside on a walkway bridge over the pond. The photo is framed with brown and green plants

Phong Le is a computational hydrologist at ORNL who is putting his skills in hydrology, numerical modeling, machine learning and high-performance computing to work quantifying water-related risks for humans and the environment. 

Photo is a high aerial view of lake superior through the clouds

Researchers at Stanford University, the European Center for Medium-Range Weather Forecasts, or ECMWF, and ORNL used the lab’s Summit supercomputer to better understand atmospheric gravity waves, which influence significant weather patterns that are difficult to forecast. 

Mengya Li is pictured here sitting at a computer in a lab.

Scientists at ORNL are studying the failure mechanisms of a new solid electrolyte battery to enhance long-term storage for renewable energy, aiming to make wind and solar power more reliable for the electric grid.