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Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair. Decoding NER’s sophisticated sequence of events and the role of PInC in the pathway could provide key insights into developing novel treatments and preventing conditions that lead to premature aging and certain types of cancer.

Ryan Culler is the program manager at Oak Ridge National Laboratory, where he oversees the production of actinium-225, a promising treatment for cancer. Driven by a personal connection to cancer through his late brother, Culler is dedicated to advancing medical isotopes to help improve cancer care. 

Scientists conducted a groundbreaking study on the genetic data of over half a million U.S. veterans, using tools from the Oak Ridge National Laboratory to analyze 2,068 traits from the Million Veteran Program.

A team of scientists with two Department of Energy Bioenergy Research Centers — the Center for Bioenergy Innovation at Oak Ridge National Laboratory and the Center for Advanced Bioenergy and Bioproducts Innovation at the University of Illinois Urbana-Champaign — identified a gene in a poplar tree that enhances photosynthesis and can boost tree height by about 30% in the field and by as much as 200% in the greenhouse. 

Using a best-of-nature approach developed by researchers working with the Center for Bioenergy Innovation at the Department of Energy’s Oak Ridge National Laboratory and Dartmouth University, startup company Terragia Biofuel is targeting commercial biofuels production that relies on renewable plant waste and consumes less energy. The technology can help meet the demand for billions of gallons of clean liquid fuels needed to reduce emissions from airplanes, ships and long-haul trucks.

Researchers used the world’s fastest supercomputer, Frontier, to train an AI model that designs proteins, with applications in fields like vaccines, cancer treatments, and environmental bioremediation. The study earned a finalist nomination for the Gordon Bell Prize, recognizing innovation in high-performance computing for science.

A team of researchers used the Frontier supercomputer and a new methodology for conducting a genome-wide association study to earn a finalist nomination for the Association for Computing Machinery’s 2024 Gordon Bell Prize for outstanding

Biochemist David Baker — just announced as a recipient of the Nobel Prize for Chemistry — turned to the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory for information he couldn’t get anywhere else. HFIR is the strongest reactor-based neutron source in the United States.  

A new Global Biomass Resource Assessment developed by ORNL scientists gathered data from 55 countries resulting in a first-of-its kind compilation of current and future sustainable biomass supply estimates around the world. 

Scientists at ORNL used neutrons to end a decades-long debate about an enzyme cancer uses.