Charles Patrick P Collier

staff researcher

Pat Collier received his Ph.D. in Physical Chemistry from the University of California at Berkeley in 1998, where he contributed to the discovery of a reversible metal-insulator transition in ordered two-dimensional superlattices of silver nanoparticles. As a joint postdoctoral associate at UCLA and Hewlett-Packard labs, he was involved in some of the first demonstrations of defect-tolerant computation in molecular electronics. As an assistant professor at the California Institute of Technology, he developed novel lithographic techniques to pattern phase-separated fluid lipid bilayers and single biological molecules at the nanoscale, and carried out the first demonstrations of electrowetting of single walled carbon nanotubes with liquid metals. He is currently a member of the research staff at the Center for Nanophase Materials Sciences (CNMS) at Oak Ridge National Laboratory, where he has helped develop methods for forming individual femtoliter-volume water-in-oil droplets in microfluidic channels on demand, and elucidate phase change behavior of water and lipid bilayer membranes on nanostructured surfaces. Current research interests include characterization of expression noise from cell-free genetic circuits confined in ultrasmall volumes, and how assembly and functionality of lipid bilayers and polymer membranes are affected by confined and crowded environments.


Young Faculty Research Initiation Award, Center for Science and Engineering of Materials (NSF MRSEC) 2004
Research Innovation Award, Research Corp., 2002
Caltech President’s Fund Award, 2002
UCLA Chancellor’s Award for Excellence in Postdoctoral Research, 2001


U.S. Patent No. 8,944,083, Issued February 3, 2015
“Generation of monodisperse femtoliter droplets by shape-induced shear and interfacial controlled fusion of individual droplets on demand”
U.S. Patent No. 8,492,160 B1, Issued July 23, 2013
“Biomarker Sensors and Method for Multi-Color Imaging and Processing of Single-Molecule Life Signatures”
U.S. Patent No. 7,514,214 B2, Issued: April 7, 2009
“Selective Functionalization of Carbon Nanotube Tips Allowing Fabrication of New Classes of Nanoscale Sensing and Manipulation Tools”
U.S. Patent No. 7,211,795 B2, Issued: May 1, 2007
“Method for Manufacturing Single Wall Carbon Nanotube Tips”
U.S. Patent No. 6,756,296 B2, Issued: June 29, 2004
U.S. Patent No. 6,979,639 B2, Issued: December 27, 2005
“Method for Lithographic Processing on Molecular Monolayer and Multilayer Thin Films”
U.S. Patent No. 6,198,655 B1, Issued: March 6, 2001
European Patent EP1236206 B1, Issued: September 13, 2006
“Electrically Addressable Volatile Non-Volatile Molecular-Based Switching Devices”